Genomic instability is one of the primary hallmarks of aging. We have seen in model organisms that mutations in DNA repair genes lead to a shortened lifespan and accelerated aging syndromes in humans. The deregulation of DNA repair genes also leads to age-related diseases, including cancer. DNA repair mechanisms, necessary for a stable genome, decline with age.. Studies in model organisms show that hormetic factors that stimulate DNA repair are capable of prolonging life. Few studies have shown the effect of overexpression of DNA repair genes on lifespan. Long-lived mammalian species (whales, bats, naked mole rats) have alterations in DNA excision repair genes and their increased expression. Thus, DNA repair is not only a hallmark but also a potential target for interventions in aging.
The purpose of this Research Topic is to consider hormetic factors (low doses of stressors), genetic and gene therapy manipulations, pharmacological interventions in preclinical or clinical studies on aging, age-related diseases and lifespan that will aid in improving DNA repair in an aging genome
This Research Topic welcomes papers addressing, but not limited to, the following topics:
• The role of DNA repair genes in aging and longevity
• Effects of genetic interventions into DNA repair genes on the aging genome
• Mechanisms of interventions into the regulation of DNA repair genes
• Pro-longevity or pro-aging effects of pharmacological interventions on DNA repair
Genomic instability is one of the primary hallmarks of aging. We have seen in model organisms that mutations in DNA repair genes lead to a shortened lifespan and accelerated aging syndromes in humans. The deregulation of DNA repair genes also leads to age-related diseases, including cancer. DNA repair mechanisms, necessary for a stable genome, decline with age.. Studies in model organisms show that hormetic factors that stimulate DNA repair are capable of prolonging life. Few studies have shown the effect of overexpression of DNA repair genes on lifespan. Long-lived mammalian species (whales, bats, naked mole rats) have alterations in DNA excision repair genes and their increased expression. Thus, DNA repair is not only a hallmark but also a potential target for interventions in aging.
The purpose of this Research Topic is to consider hormetic factors (low doses of stressors), genetic and gene therapy manipulations, pharmacological interventions in preclinical or clinical studies on aging, age-related diseases and lifespan that will aid in improving DNA repair in an aging genome
This Research Topic welcomes papers addressing, but not limited to, the following topics:
• The role of DNA repair genes in aging and longevity
• Effects of genetic interventions into DNA repair genes on the aging genome
• Mechanisms of interventions into the regulation of DNA repair genes
• Pro-longevity or pro-aging effects of pharmacological interventions on DNA repair