Mitochondria are highly dynamic and multifunctional organelles that play a central role in various key cellular metabolism and homeostasis, which includes bioenergetic supply, signaling transduction, genome stability, metabolic regulation, cell death and survival. All of these cellular processes are altered in cancer cells. Cumulative research highlights the crucial role of mitochondria in all the steps of tumorigenesis. Mitochondrial dysfunction influences diverse aspects of cancer cell development, from the initiation of tumorigenesis to tumor metastasis. On the other hand, cancer cells also can impact mitochondrial homeostasis to promote tumor cell survival and malignant progression, thus, pointing to the fundamental position of mitochondria homeostasis in oncogenesis. The growing body of evidence supports the notion that mitochondria act as the hub for signaling transduction and metabolism homeostasis in cancer, and targeting to manipulation of mitochondrial homeostasis may pave a new avenue for future cancer therapy.
However, much remains to be fully understood about the essential impact of mitochondria in cancer formation and progression. The goal of this Research Topic is to present an in-depth understanding of mitochondrial homeostasis in the pathogenesis of cancer development in the context of the novel molecular and cellular mechanisms and to bring a comprehensive overview and updated sights to the most advances in the research of mitochondrial dysfunction in tumorigenesis, cancer progression, and metastasis, and ultimately to shed new light on the potential therapeutic development and early intervention for the treatment of different types of cancers, from bench side to bedside.
In this Research Topic, we welcome the submission of original research articles, methods, perspectives, reviews, and mini-reviews addressing, but not limited to the following themes in cancer study:
-Molecular and cellular mechanisms related to mitochondria homeostasis in oncogenesis;
-Mitochondria dynamics and quality controls in oncogenesis;
-Mitochondrial genetics including genome stability and mtDNA abnormalities in cancer formation and progression;
-Mitochondrial metabolism and bioenergetics in cancer;
-Mitochondrial biogenesis and signaling regulation (including calcium homeostasis, mitochondrial unfolded protein response, communication with other subcellular organelles. etc) in cancer;
-Mitochondrial oxidative stress and cancer development;
-Mitochondrial function in the tumor immune response and chemoresistance;
-New technologies or methods to investigate the mitochondrial function in cancer;
-Mitochondrial-related biomarkers in cancer;
-Mitochondrial targeting cancer therapeutics.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Mitochondria are highly dynamic and multifunctional organelles that play a central role in various key cellular metabolism and homeostasis, which includes bioenergetic supply, signaling transduction, genome stability, metabolic regulation, cell death and survival. All of these cellular processes are altered in cancer cells. Cumulative research highlights the crucial role of mitochondria in all the steps of tumorigenesis. Mitochondrial dysfunction influences diverse aspects of cancer cell development, from the initiation of tumorigenesis to tumor metastasis. On the other hand, cancer cells also can impact mitochondrial homeostasis to promote tumor cell survival and malignant progression, thus, pointing to the fundamental position of mitochondria homeostasis in oncogenesis. The growing body of evidence supports the notion that mitochondria act as the hub for signaling transduction and metabolism homeostasis in cancer, and targeting to manipulation of mitochondrial homeostasis may pave a new avenue for future cancer therapy.
However, much remains to be fully understood about the essential impact of mitochondria in cancer formation and progression. The goal of this Research Topic is to present an in-depth understanding of mitochondrial homeostasis in the pathogenesis of cancer development in the context of the novel molecular and cellular mechanisms and to bring a comprehensive overview and updated sights to the most advances in the research of mitochondrial dysfunction in tumorigenesis, cancer progression, and metastasis, and ultimately to shed new light on the potential therapeutic development and early intervention for the treatment of different types of cancers, from bench side to bedside.
In this Research Topic, we welcome the submission of original research articles, methods, perspectives, reviews, and mini-reviews addressing, but not limited to the following themes in cancer study:
-Molecular and cellular mechanisms related to mitochondria homeostasis in oncogenesis;
-Mitochondria dynamics and quality controls in oncogenesis;
-Mitochondrial genetics including genome stability and mtDNA abnormalities in cancer formation and progression;
-Mitochondrial metabolism and bioenergetics in cancer;
-Mitochondrial biogenesis and signaling regulation (including calcium homeostasis, mitochondrial unfolded protein response, communication with other subcellular organelles. etc) in cancer;
-Mitochondrial oxidative stress and cancer development;
-Mitochondrial function in the tumor immune response and chemoresistance;
-New technologies or methods to investigate the mitochondrial function in cancer;
-Mitochondrial-related biomarkers in cancer;
-Mitochondrial targeting cancer therapeutics.
Please note: manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.