About this Research Topic
Crowds are one of the hallmarks of our times and congestions flourish everywhere. Interestingly, as it is outside, it is inside: cells possess inner organelles that are in a constant exchange of cargo, in a sort of farmer’s market that guarantees “cell sustainability”. This applies also to lymphocytes, the cells that constitute the epicenter of immune responses. Constant communication between organelle’s membranes is crucial for the turnover of molecules that either participate in an efficient immunological synapse formation and antigen recognition, secretion of immunomodulatory compounds or induce cytotoxicity. Also, labeling of inner organelles through the assembly/disassembly of giant protein complexes activate intracellular trafficking pathways that trigger the autophagy flux, apoptosis, or other cell mechanisms that define the balance between cell survival/death. These processes guarantee the mounting, intensity, and duration of adequate adaptive immune responses and define the fate of our constant interaction with the outer world.
There is scarce information about how the different organelles in the lymphocytes communicate to respond to the great variety of antigen stimuli and the role of the different multi-protein complexes in these processes. Elucidating the distinctive intracellular trafficking pathways in lymphocytes and optimizing the methods to do so, would allow the identification of new molecules with therapeutic potential in the modulation of immunity.
In this Research Topic, we welcome the submission of original research, methods, review, mini-review, systematic review, hypothesis and theory articles, clinical trials, and case reports covering aspects of intracellular trafficking in lymphocytes, with potential topics including, but not limited to:
1. Novel routes to regulate the turnover of lymphocyte molecules among the organelles and the cell membrane
2. Molecules that participate in the budding, docking, and fusion of vesicles for the secretory or endosomal pathways in lymphocytes.
3. Novel pathways for the inner communication between the endoplasmic reticulum, Golgi apparatus, and trans-Golgi network.
4. Molecules and mechanisms mediating the different forms of autophagy.
5. The different intracellular mechanisms to regulate lymphocyte survival and death in the periphery.
6. Microorganisms-related mechanisms to affect all these pathways
7. Diseases related to defects in the intracellular trafficking in lymphocytes
8. New methods to improve the study of intracellular trafficking in lymphocytes
There is scarce information about how the different organelles in the lymphocytes communicate to respond to the great variety of antigen stimuli and the role of the different multi-protein complexes in these processes. Elucidating the distinctive intracellular trafficking pathways in lymphocytes and optimizing the methods to do so, would allow the identification of new molecules with therapeutic potential in the modulation of immunity.
In this Research Topic, we welcome the submission of original research, methods, review, mini-review, systematic review, hypothesis and theory articles, clinical trials, and case reports covering aspects of intracellular trafficking in lymphocytes, with potential topics including, but not limited to:
1. Novel routes to regulate the turnover of lymphocyte molecules among the organelles and the cell membrane
2. Molecules that participate in the budding, docking, and fusion of vesicles for the secretory or endosomal pathways in lymphocytes.
3. Novel pathways for the inner communication between the endoplasmic reticulum, Golgi apparatus, and trans-Golgi network.
4. Molecules and mechanisms mediating the different forms of autophagy.
5. The different intracellular mechanisms to regulate lymphocyte survival and death in the periphery.
6. Microorganisms-related mechanisms to affect all these pathways
7. Diseases related to defects in the intracellular trafficking in lymphocytes
8. New methods to improve the study of intracellular trafficking in lymphocytes
Keywords: Intracellular trafficking, Intracellular compartments, Receptor turnover, COATomer, Intracellular vesicles, Rab GTPases, V-SNARE/t-SNARE, Lymphocyte death, Lymphocyte survival, Lymphocyte activation, Lymphocyte anergy, Cytotoxicity, Organelle biogenesis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
