The global burden of stroke is extremely high, and stroke-induced cerebral edema is the major cause of rapid death after stroke. Research into the mechanism of brain edema formation and development has a long history. From the imaging point of view, two main types are distinguished: One is to detect the free and bound water in the brain as much as possible based on the development of imaging technology. The other is to use imaging markers to indirectly reflect or predict brain edema based on the principle of edema formation. Edema after stroke is mainly considered as cytotoxic edema and angiogenic edema. According to the principle of brain tissue density change caused by post-stroke cytotoxic edema, many imaging evaluation methods have been developed based on CT. Another example is the mechanism of angiogenic edema related to blood-brain barrier (BBB) injury, so there are many imaging analysis methods to predict the progression of brain edema by assessing BBB permeability ( BBBP ). As another example, recent studies have shown that cerebrospinal fluid inflow after stroke is closely related to the formation of interstitial cerebral edema, prompting researchers to address the relevant mechanisms of structural and functional abnormalities of the brain glymphatic system after stroke.
Although there have been recent breakthroughs in the field of brain edema, brain edema formation is the result of multiple mechanisms mediated by a variety of brain tissue structures. Currently, research on the mechanism of brain edema still lacks mutual verification between animal studies and human images, i.e. there is a discrepancy between basic research and clinical research; moreover, these mechanisms and the role of each brain tissue system in the development of brain edema have not been sufficiently explored, so further research is needed in the following aspects 1) verification of the brain edema mechanism revealed by basic imaging research in humans; 2) cerebral arteriovenous structure, glymphatic system and cerebral microcirculation are imaging markers involved in the formation of brain edema after stroke; 3) evaluation and differentiation of various types of brain edema after stroke by advanced imaging techniques; 4) whether the influence of other diseases on the nervous system (i.e. i.e., the basis of nervous system injury) is the comorbid mechanism of post-stroke brain edema; etc.
Exploration of this Research Topic will expand the understanding of the mechanism of brain edema, promote the use of imaging techniques in the evaluation of post-stroke brain edema, and provide clues for clinical prevention or early intervention of post-stroke brain edema, including:
- Cross-validation of biomarkers and human imaging markers in post-stroke brain edema;
- Novel imaging techniques to assess post-stroke brain edema;
- How functional and structural changes of the brain, including the cerebral arteriovenous system, glymphatic system, blood-brain barrier permeability, etc., are involved in post-stroke brain edema using imaging techniques;
- Investigate the comorbid mechanism of underlying diseases (including but not limited to small cerebral vessel diseases) in the development of post-stroke cerebral edema using imaging techniques;
- Imaging assessment of the mechanism of hematoma-related edema after hemorrhagic stroke, including intracranial hemorrhage and subarachnoid hemorrhage.
The global burden of stroke is extremely high, and stroke-induced cerebral edema is the major cause of rapid death after stroke. Research into the mechanism of brain edema formation and development has a long history. From the imaging point of view, two main types are distinguished: One is to detect the free and bound water in the brain as much as possible based on the development of imaging technology. The other is to use imaging markers to indirectly reflect or predict brain edema based on the principle of edema formation. Edema after stroke is mainly considered as cytotoxic edema and angiogenic edema. According to the principle of brain tissue density change caused by post-stroke cytotoxic edema, many imaging evaluation methods have been developed based on CT. Another example is the mechanism of angiogenic edema related to blood-brain barrier (BBB) injury, so there are many imaging analysis methods to predict the progression of brain edema by assessing BBB permeability ( BBBP ). As another example, recent studies have shown that cerebrospinal fluid inflow after stroke is closely related to the formation of interstitial cerebral edema, prompting researchers to address the relevant mechanisms of structural and functional abnormalities of the brain glymphatic system after stroke.
Although there have been recent breakthroughs in the field of brain edema, brain edema formation is the result of multiple mechanisms mediated by a variety of brain tissue structures. Currently, research on the mechanism of brain edema still lacks mutual verification between animal studies and human images, i.e. there is a discrepancy between basic research and clinical research; moreover, these mechanisms and the role of each brain tissue system in the development of brain edema have not been sufficiently explored, so further research is needed in the following aspects 1) verification of the brain edema mechanism revealed by basic imaging research in humans; 2) cerebral arteriovenous structure, glymphatic system and cerebral microcirculation are imaging markers involved in the formation of brain edema after stroke; 3) evaluation and differentiation of various types of brain edema after stroke by advanced imaging techniques; 4) whether the influence of other diseases on the nervous system (i.e. i.e., the basis of nervous system injury) is the comorbid mechanism of post-stroke brain edema; etc.
Exploration of this Research Topic will expand the understanding of the mechanism of brain edema, promote the use of imaging techniques in the evaluation of post-stroke brain edema, and provide clues for clinical prevention or early intervention of post-stroke brain edema, including:
- Cross-validation of biomarkers and human imaging markers in post-stroke brain edema;
- Novel imaging techniques to assess post-stroke brain edema;
- How functional and structural changes of the brain, including the cerebral arteriovenous system, glymphatic system, blood-brain barrier permeability, etc., are involved in post-stroke brain edema using imaging techniques;
- Investigate the comorbid mechanism of underlying diseases (including but not limited to small cerebral vessel diseases) in the development of post-stroke cerebral edema using imaging techniques;
- Imaging assessment of the mechanism of hematoma-related edema after hemorrhagic stroke, including intracranial hemorrhage and subarachnoid hemorrhage.
