One Health and Veterinary Regenerative Medicine: Translational Applications

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About this Research Topic

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Background

Regenerative Medicine has been touted as having the potential to provide needed treatments and/or cures for
many significant diseases in human and veterinary medicine. However, that potential has yet to be realized.
Recent years and the current pandemic have brought more attention to the deficits in current systems as well as the benefits of collaboration, team science, and One Health approaches. Veterinary medicine and naturally
occurring diseases in animals can provide impactful information to human diseases and help direct and refine new treatments to the betterment of both human and animal health as well as the environment. A thorough assessment of the strengths, gaps, and priorities in veterinary and human regenerative medicine will identify the necessary steps to allow realization of the benefits of collaboration and a One Health approach to accelerate the progress of regenerative therapies.

With this Research topic, we would like to highlight the current state of veterinary regenerative medicine in relation to translational/One Health applications. In this way, this Research topic will serve as an analysis of strengths, gaps, and priorities in both the veterinary and human regenerative medicine space, and thereby provide a means of encouraging collaboration and a call to action on areas of need in both fields to more fully realize the potential in regenerative therapies.

This Research Topic will accept papers including, but not limited to:

• Regulatory topics, differences, and hurdles in veterinary regenerative medicine
• Articles on the current state of regulation in veterinary regenerative medicine, including comparisons between veterinary species, to human regenerative medicine, and across regulatory agencies.
• Articles on the regulatory hurdles facing veterinary regenerative medicine with regard to technology, uptake to the clinic, regulation, etc. and how to overcome them (e.g. culture methods, scale
up, standardization, cell characterization, etc.), to product approval, including comparison to human regenerative medicine.

• Safety and efficacy issues/studies in veterinary regenerative medicine
• Review and original research articles on experiences, challenges, and best practice recommendations for demonstrating safety and efficacy of veterinary regenerative products for regulatory
approval, specific conditions, and to improve translation of studies.

• Challenges in veterinary clinical studies, including study quality and ethical discussions
• Review articles and opinion pieces evaluating current study quality and recommendations/best
practices for improving study quality in veterinary clinical studies using regenerative therapies,
including article editor and reviewer standards.
• Articles discussing the ethical considerations associated with current veterinary regenerative
medicine including regulatory requirements, use of companion animals as human models or in
One Health approaches, use of therapies with limited evidence of efficacy, and comparisons with
human medicine.

• Current naturally occurring animal models, including scope, status, regenerative therapy types
• In-depth review articles on the naturally occurring animal models available for different conditions
and therapies.
• Original research articles on the development of new animal models or in vitro technologies to
minimize the use of animals in research in regenerative medicine.

• Sustainability in regenerative medicine
• Review or original research articles describing the intensive resource requirements of regenerative medicine and novel ways to decrease the use of non-reusable consumables and other resources in order to decrease the negative environmental and health impacts of the field.

Keywords: One Health, Veterinary, regenerative, animal model, clinical studies, regulatory

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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