Lipid Metabolism and human diseases

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Editorial

04 November 2022

Editorial: Lipid metabolism and human diseases

Peter U. Amadi

,

Hong-Mei Gu

,

Kai Yin

,

Xian-Cheng Jiang

and

Da-wei Zhang

5,154 views

1 citations

Editors

3

Da-wei Zhang

University of Alberta

Xian-Cheng Jiang

Downstate Health Sciences University

Kai Yin

Guilin Medical University

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About

Lipids such as cholesterol, phospholipids, triglycerides, and free fatty acids, play various essential physiological roles. Dysregulation of lipid metabolism causes dyslipidemia, which is a critical factor in the development of various human diseases, such as cardiovascular disease, diabetes, non-alcoholic fatty liver disease, Alzheimer's disease, and Niemann-Pick disease. Therefore, lipid homeostasis in humans is strictly regulated by a well-balanced mechanism of intestinal uptake, endogenous synthesis and metabolism, and transport in lipoprotein particles and excretion.

The human body evolves multiple mechanisms to maintain lipid homeostasis, such as low-density lipoprotein receptor mediates clearance of circulating low-density lipoprotein cholesterol; phospholipid transfer protein mediates the transfer of phospholipids from apoB-containing triglyceride-rich lipoprotein to high-density lipoprotein, etc.

This Research Topic focuses on the molecular mechanisms of proteins and pathways relevant to lipid metabolism and human disease and the translation of this knowledge to develop novel therapeutics with improved efficacy.

This Research Topic welcomes Original Research and Review articles on:
1) Cholesterol metabolism including cholesterol uptake, efflux and transport.
2) Metabolism of circulating lipoproteins.

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Editors

Da-wei Zhang

University of Alberta

Xian-Cheng Jiang

Downstate Health Sciences University

Kai Yin

Guilin Medical University

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75,833 Total views

52,677 Article views

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2,927 Topic views

Published In

Frontiers in Physiology

Lipid and Fatty Acid Research, Metabolic Physiology

Frontiers in Cell and Developmental Biology

Lipid and Fatty Acid Research

Frontiers in Nutrition

Lipid and Fatty Acid Research

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