Cardiovascular Neuromodulation: Mechanisms and therapies

Overview of the neurocardiac axis and invasive neuromodulation approaches [Adapted from Chen et al., (10)].

Editorial

23 May 2023

Editorial: Cardiovascular neuromodulation: mechanisms and therapies

Deborah Hunt

Marco Mongillo

Marianna Meo

Tania Zaglia

and

Khaled Qanud

2,163 views

0 citations

Editors

Marianna Meo

Boston Scientific

Khaled Qanud

Feinstein Institute for Medical Research

Department of Biomedical Sciences, University of Padova

Impact

Validation of the hub genes. Boxplots showing the expression level of six real hub genes in dataset GSE149899. *P < 0.05, ** P < 0.01, *** P < 0.001, ns, no significance. CTR, control; R-PAH, reversible pulmonary arterial hypertension; IR-PAH, irreversible pulmonary arterial hypertension.

Original Research

06 October 2022

Weighted gene co-expression network analysis identifies dysregulated B-cell receptor signaling pathway and novel genes in pulmonary arterial hypertension

Yuanrong Chen

, 7 more and

Genfa Xiao

3,542 views

1 citations

Original Research

26 July 2022

Hyperthermia as a trigger for Takotsubo syndrome in a rat model

Matthew H. Tranter

, 5 more and

Sian E. Harding

2,669 views

5 citations

Heart rate dynamics in naïve female Homo and Het mice. (A) ECGs recorded in Homo and Het female mice. Traces for the three leads and RR interval duration are reported. (B) Quantitative data for average RR interval duration. (C) Data for time-domain parameters of HRV. SDRR, standard deviation of RR intervals; CVRR, coefficient of variation of RR intervals; RMSSD, square root of the mean of the squared differences between adjacent RR. (D) Data for frequency-domain parameters of HRV. (E) Data for frequency bands normalized by total power. (F) Data for LF/HF ratio. (G) Poincaré plots obtained from ECGs recorded from female Homo and Het mice reported in A. RRn and RRn+1 axes span from 75 to 110 ms. (H) Data for non-linear indices. Quantitative data were obtained from naïve Homo (n = 17) and Het (n = 10) female mice. Data are shown as scattered plots with median and interquartile ranges. ns, not significant, ***P < 0.001, ****P < 0.0001 using unpaired t-test or Mann-Whitney test.

Original Research

02 May 2022

Heart Rate Variability Reveals Altered Autonomic Regulation in Response to Myocardial Infarction in Experimental Animals

Emanuele Pizzo

, 6 more and

Marcello Rota

6,619 views

12 citations

Schematic representation of the experimental setup and decoding algorithm from Vallone et al. (152). (A) Recording apparatus, electrode implantation and summary of the in vivo protocol and functional challenges comparisons. (B) Decoding algorithm. Feature extraction was performed on 1 s portions of raw intraneural signals (dark blue traces) by applying principal component analysis on wavelet details relative to two different scales (1,500 Hz < f < 3,000 Hz and 3,000 Hz < f < 6,000 Hz). Neural signals recorded with intraneural electrodes were a combination of single-unit and compound action potentials. Decoding performed with ensemble learning based on classification trees combined with random undersampling and boosting procedure was applied on feature vectors. Decoding performance was assessed by means of confusion matrices and accuracy level. (C) Schematic description of two intraneural electrodes implantation in the VN of one pig and hybrid model simulations of fascicles activation at baseline and in response to functional challenges. The two intraneural electrodes are represented on a VN histological section (central panels). DFP patterns of activity during baseline and each functional challenge (left panels). DFP, discriminative field potentials. Adapted from Vallone et al. (152) with permission.

Review

07 April 2022

Closed-Loop Vagus Nerve Stimulation for the Treatment of Cardiovascular Diseases: State of the Art and Future Directions

Matteo Maria Ottaviani

, 2 more and

Fabio A. Recchia

16,493 views

31 citations

Short-term intervention (10 sessions): Linear regression analysis was carried out and, if the slope of the regression line is significantly larger than 0 with P < 0.05, the linear regression (solid line) and its 95% confidence interval (dotted lines) are plotted as well. (A) LF-PI and Central SBP [r = 0.5315; P =0.0063]; (B) LF-PI and Cortisol levels [r = 0.7058; P < 0.0001]; (C) HF-PI and IL-10 levels [r = 0.5344; P = 0.0049]; (D) IL-10 and AIx (@HR75%) [r = −0.6522; P = 0.0003].

Original Research

11 March 2022

Acute and Short-Term Autonomic and Hemodynamic Responses to Transcranial Direct Current Stimulation in Patients With Resistant Hypertension

Bruno Rodrigues

, 9 more and

Heitor Moreno-Junior

3,382 views

11 citations

Original Research

14 March 2022

Sustained Downregulation of Vascular Smooth Muscle Acta2 After Transient Angiotensin II Infusion: A New Model of “Vascular Memory”

Lucie Pothen

, 10 more and

Jean-Luc Balligand

3,649 views

2 citations

Schematic diagram illustrating the errant preganglionic fiber and collateral hypotheses. In the preganglionic hypothesis (left), mis-routed cholinergic (black) preganglionic fibers travel back up the efferent nerves through which sympathetic axons travel to the target tissue. In the collateral hypothesis (right) postganglionic sympathetic neurons send noradrenergic projections (red) to the target tissue and cholinergic projections (black) to other sympathetic neurons in the sympathetic chain ganglia.

Perspective

10 February 2022

Untangling Peripheral Sympathetic Neurocircuits

Courtney Clyburn

, 2 more and

Beth A. Habecker

5,298 views

5 citations

Monocyte-macrophages from the stellate ganglia of SHR n = 5 samples, 3 rats per sample, and age-matched Wistars (n = 4 samples, 3 rats per sample) at 5–6 weeks (developing hypertension) and 12–18 weeks (established hypertension). (A) Flow cytometry plots of all samples; each color represents a separate sample of ganglia from 2–3 rats. (B) Classical/non-classical monocyte-macrophage ratio from all 5-18 week old animals; Data are expressed as mean ± SEM. *signifies p < 0.05 WST vs. SHR, Welch's t-test.

Original Research

27 January 2022

Macrophages Can Drive Sympathetic Excitability in the Early Stages of Hypertension

Oliver C. Neely

, 1 more and

David J. Paterson

3,379 views

7 citations

Scatter plots of HRVI numerator and denominator coded for atrial fibrillation or sinus rhythm (A), cardiovascular (B), and all-cause mortality (C). HRVI, heart rate variability triangular index.

Original Research

29 November 2021

U-Shaped Association of the Heart Rate Variability Triangular Index and Mortality in Hemodialysis Patients With Atrial Fibrillation

Matthias C. Braunisch

, 21 more and

Christoph Schmaderer

2,779 views

1 citations

Open for submission

Frontiers in Molecular Biosciences

The Upcoming Complications of COVID-19 on Recovered Patients: Molecular Mechanisms and Therapeutic Opportunities

Edited by Rana Jahanban-Esfahlan, Zohreh Amoozgar, Seyed Hassan Seradj, William C Cho

152.6K

views

authors

articles

Frontiers in Molecular Biosciences

The Upcoming Complications of COVID-19 on Recovered Patients: Molecular Mechanisms and Therapeutic Opportunities

Edited by Rana Jahanban-Esfahlan, Zohreh Amoozgar, Seyed Hassan Seradj, William C Cho

152.6K

views

authors

articles

Frontiers in Molecular Biosciences

Fibrotic Tissue Remodeling as a Driver of Disease Pathogenesis

Edited by Trayambak Basak, Sarika Saraswati

31.4K

views

authors

articles

Frontiers in Molecular Biosciences

Volume II: Fibrotic Tissue Remodeling as a Driver of Disease Pathogenesis

Edited by Trayambak Basak, Sarika Saraswati, ARKADEEP MITRA

20.2K

views

authors

articles

Frontiers in Molecular Biosciences

Advances in Alzheimer’s Disease Diagnostics, Brain Delivery Systems and Therapeutics

Edited by Ashok Iyaswamy, Abhimanyu Thakur, Raymond Chuen-Chung Chang, Chuanbin Yang

17.1K

views

authors

articles

Frontiers in Molecular Biosciences

Circulatory Epigenetic Signatures: A Promise for Early Detection of Cancer, Cardiovascular and Neurodevelopmental Diseases

Edited by Manisha Sachan, Vidisha Tripathi, Gaurav Kumar Pandey, Kazuhiko Nakabayashi

11.1K

views

authors

articles