Maintenance of genome stability is an absolute requirement for cell survival and transmission of genetic information to the progeny. For this reasons, nuclear DNA needs to be protected from any lesions. To counteract these lesions and preserve genome stability, cells evolved a molecular system known as the DNA-damage response (DDR). Previously it has been thought that DDR involves only enzymatic reactions carried out by proteins facilitating signalling as well as the repair process. However, several reports have implicated the function of RNA in this phenomenon. Thus, it seems important to address the question regarding the mechanism by which RNA molecules, RNA-related proteins as well as RNA modifications stimulate maintenance of genome stability.
The aim of this Research Topic is to provide novel evidence and summarize existing data that help us to understand the function of RNA molecules and its modifications in DNA damage and repair process.
These articles may include but are not limited to following topics:
• Epigenetic marks influencing DSB repair
• Relationship between RNAs and DNA damage repair
• Transcription-coupled repair mechanisms
• Factors that influence DNA-RNA hybrids at DNA double strand breaks (DSBs)
• Interference of the RNA metabolism with DNA repair mechanisms
Maintenance of genome stability is an absolute requirement for cell survival and transmission of genetic information to the progeny. For this reasons, nuclear DNA needs to be protected from any lesions. To counteract these lesions and preserve genome stability, cells evolved a molecular system known as the DNA-damage response (DDR). Previously it has been thought that DDR involves only enzymatic reactions carried out by proteins facilitating signalling as well as the repair process. However, several reports have implicated the function of RNA in this phenomenon. Thus, it seems important to address the question regarding the mechanism by which RNA molecules, RNA-related proteins as well as RNA modifications stimulate maintenance of genome stability.
The aim of this Research Topic is to provide novel evidence and summarize existing data that help us to understand the function of RNA molecules and its modifications in DNA damage and repair process.
These articles may include but are not limited to following topics:
• Epigenetic marks influencing DSB repair
• Relationship between RNAs and DNA damage repair
• Transcription-coupled repair mechanisms
• Factors that influence DNA-RNA hybrids at DNA double strand breaks (DSBs)
• Interference of the RNA metabolism with DNA repair mechanisms