GPCRs: structure, signal transduction, and contribution in pathophysiology

130.1K

views

67

authors

13

articles

Editors

3

Claudio M COSTA-NETO

University of São Paulo

Paul Scherrer Institut (PSI)

Gebhard F. X. Schertler

Impact

About

G protein coupled-receptors (GPCRs) or seven-transmembrane receptors (7TMRs) are the most prevailing class of signaling transduction molecules in human organism, being activated by a diversity of ligands such as peptides, large proteins, lipids, small organic molecules, ions, and others. Classically, GPCRs transduce signals by means of heterotrimeric G proteins but more recently other mechanisms and signaling pathways have been reported. GPCRs are involved in plethora of pathophysiological processes and many drugs act by modulating GPCRs’ activities. It is estimated that ca. 40% of all drugs in the market act on GPCRs. In the last years key advances concerning to GPCRs’ structure, signaling properties, and evidences of their involvement in many pathophysiological events were achieved; which shall impact the development of next-generation drugs.

G protein coupled-receptors (GPCRs) or seven-transmembrane receptors (7TMRs) are the most prevailing class of signaling transduction molecules in human organism, being activated by a diversity of ligands such as peptides, large proteins, lipids, small organic molecules, ions, and others. Classically, GPCRs transduce signals by means of heterotrimeric G proteins but more recently other mechanisms and signaling pathways have been reported. GPCRs are involved in plethora of pathophysiological processes and many drugs act by modulating GPCRs’ activities. It is estimated that ca. 40% of all drugs in the market act on GPCRs. In the last years key advances concerning to GPCRs’ structure, signaling properties, and evidences of their involvement in many pathophysiological events were achieved; which shall impact the development of next-generation drugs.

Share

Editors

Claudio M COSTA-NETO

University of São Paulo

Paul Scherrer Institut (PSI)

Gebhard F. X. Schertler

Impact

130,087 Total views

96,476 Article views

28,600 Article downloads

5,011 Topic views

Published In

Journal Thumbnail

Frontiers in Pharmacology

Experimental Pharmacology and Drug Discovery

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic