New Perspectives on Osteoclasts in Health and Disease

  • 18k

    Total Downloads

  • 84k

    Total Views and Downloads

About this Research Topic

Submission closed

Background

The bone marrow system is responsible for skeletal development and bone remodeling throughout life, thanks to the finely regulated activity of the bone-resorbing osteoclasts and the bone-forming osteoblasts. To maintain bone homeostasis, bone-residing cells establish dynamic cross-communications between the bone and the mesenchymal-stromal, hematopoietic, endothelial, muscle, immune and neural systems.
Dysregulation in this crosstalk and in the bone microenvironment leads to alterations in bone development and quality, resulting in the onset of pathologies including osteoporosis, osteoarthritis, osteomalacia, bone-homing tumors and fractures but also alterations in hematopoiesis, immune or neuronal responses or vascularization.

In the recent years, the central role of osteoclasts in this crosstalk has been emphasized by in-depth analysis of the mechanisms regulating their formation and activity as well as their communication with their environment. Therefore, osteoclasts appear as key targets for the development of novel pharmacological or cellular approaches for the diagnosis and therapy for pathologies related to bone destruction and beyond.

This Research Topic is devoted to provide a profound comprehension of the regulatory mechanisms involved in the function and differentiation of osteoclasts, in their interaction with the bone marrow environment, as well as their implication in diseases. It will also cover the potential of osteoclasts as cellular targets for the prevention and/or treatment of bone pathologies. A better understanding of the relevant molecular mechanisms governing osteoclast activation and function by surrounding cells and systems could pave the way for the development of novel therapeutic strategies.

We welcome contributions of different types of articles including original research articles, hypotheses and theory, as well as reviews and mini reviews on osteoclast pathophysiology, in particular the following
themes:

• Implication of osteoclasts in pathological conditions including rare diseases, chronic rheumatic diseases, cancer, infection, osteoporosis;
• Perspectives in pharmacological targeting of osteoclasts for diagnosis and treatment of bone pathologies;
• Membrane receptors and cell signaling in osteoclast physiology and dysfunctions;
• The role of metabolism in osteoclast physiopathology;
• Osteoclast differentiation, fusion and function;
• Osteoclast plasticity and interaction with bone marrow cells, including osteoimmunology;
• The role of circulome (extracellular vesicles, nanotunnels, microRNAs, long non-coding RNAs, etc) in osteoclast development and activity.

Keywords: Osteoimmunology, bone pathologies, cell metabolism, circulome, bone marrow environment.

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Participating Journals

Impact

  • 84kTopic views
  • 63kArticle views
  • 18kArticle downloads
View impact