About this Research Topic
Regarding the mechanism of kidney and heart failure protection of SGLT2 inhibitors and strategies for how to best implement these new agents in the clinical management of patients with CKD. The key topics we propose to address in this issue are: 1) How do SGLT2 inhibitors precisely protect heart and kidney function? 2) How do we best implement the findings from clinical trials in clinical practice? 3) What is the optimal position of SGLT2 inhibitors next to many other drugs used in patients with heart failure and chronic kidney disease? 4) What is the role for combination therapies?
In this special issue of Frontiers we solicit original research articles, commentaries, opinions and reviews about SGLT2 inhibitors in patients with CKD. The articles should deal with any of the following topics including but not limited to the below:
• Mechanism of action of SGLT2 inhibitors with respect to heart and kidney protection. Pre-clinical and clinical studies can be submitted.
• Opinions and perspectives how SGLT2 inhibitors modify the cardio-renal axis.
• Interaction of SGLT2 inhibitors with other cardiorenal protective agents as well as gaps in trials looking into combination therapies trials with SGLT2 (ie GLP-1 RA, finerenone)
• Integrated discussion with respect to the different guidelines across the medical specialties
Keywords: SGLT2 inhibition; cardiovascular disease; heart failure; diabetic kidney disease; type 2 diabetes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.