Since December 2019, the infectious illness caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2), called “coronavirus disease-19” (COVID-19), has rapidly spread throughout the world becoming a pandemic emergency. In addition to common systemic manifestations such as fever and pneumonia, COVID-19 has been documented to be associated with different extra-pulmonary signs, including skin manifestations. Although the pathophysiological basis of COVID-19-associated skin lesions is still largely unknown and the role of SARS-CoV-2 in their pathogenesis is still debated, it may be postulated that the direct hematogenous spread of the virus in the skin may be responsible for certain clinical patterns, while the hyper-inflammatory response secondary to the systemic infection may lead to other skin phenotypes. Moreover, as COVID-19 vaccine administration increases, recognition and understanding of novel vaccine-related skin reactions are essential.
The aim of this Research Topic is to gather a collection of basic Review articles and Original Research articles on COVID-19-associated skin manifestations and COVID-19 vaccine-related cutaneous reactions in order to (i) provide an update on epidemiological and clinical features of these conditions; (ii) promote improved understanding of their physiopathological basis; (iii) identify possible correlations between the extent of skin manifestations and COVID-19 severity, and (iv) pave the way to a pathogenesis-driven therapeutic approach.
In this Research Topic, we welcome the submission of Reviews, Mini-Revies, Original Research Articles, Case Series, and Case Reports that cover the following topics on COVID-19-associated skin manifestations and COVID-19 vaccine-related cutaneous reactions:
• Genetics
• Role of immune cells and cytokines
• Autoinflammation and COVID-19-associated skin manifestations
• Urticarial rash
• Confluent erythematous-maculopapular-morbilliform rash
• Papulovesicular exanthem
• Chilblain-like acral pattern
• Livedo reticularis-livedo racemosa-like pattern
• Purpuric 'vasculitic' pattern
• Multisystem inflammatory syndrome in children (MIS-C)
• Telogen effluvium
• COVID-19 vaccine-related skin reactions
• New therapeutic approaches
Since December 2019, the infectious illness caused by the “severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2), called “coronavirus disease-19” (COVID-19), has rapidly spread throughout the world becoming a pandemic emergency. In addition to common systemic manifestations such as fever and pneumonia, COVID-19 has been documented to be associated with different extra-pulmonary signs, including skin manifestations. Although the pathophysiological basis of COVID-19-associated skin lesions is still largely unknown and the role of SARS-CoV-2 in their pathogenesis is still debated, it may be postulated that the direct hematogenous spread of the virus in the skin may be responsible for certain clinical patterns, while the hyper-inflammatory response secondary to the systemic infection may lead to other skin phenotypes. Moreover, as COVID-19 vaccine administration increases, recognition and understanding of novel vaccine-related skin reactions are essential.
The aim of this Research Topic is to gather a collection of basic Review articles and Original Research articles on COVID-19-associated skin manifestations and COVID-19 vaccine-related cutaneous reactions in order to (i) provide an update on epidemiological and clinical features of these conditions; (ii) promote improved understanding of their physiopathological basis; (iii) identify possible correlations between the extent of skin manifestations and COVID-19 severity, and (iv) pave the way to a pathogenesis-driven therapeutic approach.
In this Research Topic, we welcome the submission of Reviews, Mini-Revies, Original Research Articles, Case Series, and Case Reports that cover the following topics on COVID-19-associated skin manifestations and COVID-19 vaccine-related cutaneous reactions:
• Genetics
• Role of immune cells and cytokines
• Autoinflammation and COVID-19-associated skin manifestations
• Urticarial rash
• Confluent erythematous-maculopapular-morbilliform rash
• Papulovesicular exanthem
• Chilblain-like acral pattern
• Livedo reticularis-livedo racemosa-like pattern
• Purpuric 'vasculitic' pattern
• Multisystem inflammatory syndrome in children (MIS-C)
• Telogen effluvium
• COVID-19 vaccine-related skin reactions
• New therapeutic approaches
