Autoimmune Blistering Diseases, volume II

131.3K

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263

authors

38

articles

Autoimmune Blistering Diseases, volume II

131.3K

views

263

authors

38

articles

Editorial

16 March 2023

Editorial: Autoimmune blistering diseases, volume II

Xiaoguang Li

,

Giovanni Di Zenzo

,

Enno Schmidt

,

Pascal Joly

and

Takashi Hashimoto

1,535 views

1 citations

Editors

5

Pascal Joly

Centre Hospitalier Universitaire (CHU) de Rouen

Enno Schmidt

University of Lübeck

TAKASHI HASHIMOTO

Graduate School of Medicine, Osaka City University

Giovanni Di Zenzo

Istituto Dermopatico dell'Immacolata (IDI)-IRCCS

Xiaoguang Li

Daqing Oilfield General Hospital

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About

Given the success of Volume I of this Research Topic, we are pleased to announce the launch of Volume II: “Autoimmune Blistering Diseases”.

Autoimmune Blistering Diseases (AIBDs) are rare, intractable and possibly fatal organ-specific autoimmune diseases of the skin that are characterized clinically by blister formation on the skin and various mucous membranes, and immunologically by the presence of anti-skin autoantibodies mainly comprised of the IgG and IgA subclasses. AIBDs are classified into two major groups: 1. Pemphigus diseases and 2. Pemphigoid diseases, which are characterized by autoantibodies against desmosomal structural proteins or the hemi-desmosomal anchoring complex, respectively.

Recent immunological, biochemical and molecular biology studies have identified various novel autoantigens that trigger AIBDs, leading to the proposal of a new classification system for a number of different types of AIBDs. In addition, previous studies using various disease models have deepened our insight into the pathogenesis of some types of AIBDs, including pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid and epidermolysis bullosa acquisita, leading to the proposal of novel and safe therapeutic options. However, despite these important findings, the true pathogenic mechanisms underlying most types of AIBDs have not yet been clarified, and ideal treatments remain to be established.

In this Research Topic, we welcome the submission of Original Research, Review, Methods, Protocol, Systematic Review, Mini Review, Hypothesis and Theory, Perspective, Clinical Trial, Clinical Study Protocol, Case Report, Classification and Opinion articles that shed light on the recent progress in research on various aspects of AIBDs, including, but not limited to:

(i) Identification and characterization of unidentified skin autoantigens
(ii) Classification of different AIBDs
(iii) Studies of the immunological pathogenesis of AIBDs using various disease models
(iv) Identification of novel therapeutic options for patients with AIBDs
(v) Clinical trials related to AIBDs

We aim to increase awareness of AIBDs and to foster the development of ideal treatments for not only AIBDs but also for other types autoimmune diseases.

Dr. Enno Schmidt receives grant funding from Euroimmun, Incyte, UCB, Admirx, Synton/biondis, Biotest, Fresenius Medical Care, Dompe, and AstraZeneca and is a co-inventor on a patent with Euroimmun. The other Topic Editors declare no potential competing interests in relation to the Research Topic theme.

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Editors

Pascal Joly

Centre Hospitalier Universitaire (CHU) de Rouen

Enno Schmidt

University of Lübeck

TAKASHI HASHIMOTO

Graduate School of Medicine, Osaka City University

Giovanni Di Zenzo

Istituto Dermopatico dell'Immacolata (IDI)-IRCCS

Xiaoguang Li

Daqing Oilfield General Hospital

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131,312 Total views

90,351 Article views

38,737 Article downloads

2,224 Topic views

Published In

Frontiers in Immunology

Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders, Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

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