With the rapid development of industry, agriculture, transportation and sports, the injuries caused by various accidents are rapidly increasing. Multiple tissues can be damaged during trauma, including bone, muscle, cartilage, and skin, which provide support, stability, and movement to our body. Severe tissue defect has poor outcomes and current treatment options for tissue regeneration are limited. Nevertheless, the development of stem cell-based therapy has brought a new future on tissue regenerative medicine over the past few decades.
Tissue repair and regeneration is a complex and dynamic physiological process subdivided into four coordinated, continuous, and overlapping stages: hemostasis, inflammation, hyperplasia, and remodeling. Stem cells can be involved in this process, and stem-cell therapy is currently being given the utmost research importance. With the development of regenerative medicine, stem cell transplantation has been considered as a viable option to treat various refractory clinical diseases. These cells have great therapeutic potential due to their ability to self-replicate, differentiate, and regulate hematopoietic and immune cells. For example, osteoblastic differentiation is a vital process during bone remodeling and fracture healing, and is regulated by an array of biological factors. Mesenchymal stem cells (MSCs) are capable to be stimulated towards osteoblasts, and are the main healing-promoting cell type in fracture healing. In addition, MSCs are a kind of precursor cell with a series of therapeutic molecules, with the ability to respond to the surrounding microenvironment. Moreover, MSCs can regulate their own fate and behavior by sensing the surrounding microenvironment for indicators such as inflammation, infection, or tissue damage.
In this Research Topic, we aim to collect original research and review articles that will improve our understanding on the regenerative mechanisms of multiple tissues damaged by trauma, such as bone, muscle, cartilage, and skin. In addition, we welcome original research investigating the importance of the communication between physical stimulus and stem cells in the application of tissue repair strategies.
Potential topics include but are not limited to the following:
1. Stem cells-based treatments for tissue regeneration
2. The role of cytokines, chemokines, and exosomes in stem cell-based transplantation and therapeutics in tissue repair and regeneration
3. Mechanism of stem cell therapy regulated by immune system
4. Novel molecular mechanisms, mechanical stimuli, and biomaterial design for the directional differentiation of stem cells in vivo and in vitro
5. Stem cells interactions with the microenvironment in physiological and pathological conditions
6. Identity and subpopulation of novel stem cells
7. Application of mesenchymal stem cell-based therapy (extracted from bone marrow, adipose tissue, placenta, or other organs) for tissue repair and regeneration
8. System review of stem cells and stem cell-based biomaterials in the application of tissue regeneration
With the rapid development of industry, agriculture, transportation and sports, the injuries caused by various accidents are rapidly increasing. Multiple tissues can be damaged during trauma, including bone, muscle, cartilage, and skin, which provide support, stability, and movement to our body. Severe tissue defect has poor outcomes and current treatment options for tissue regeneration are limited. Nevertheless, the development of stem cell-based therapy has brought a new future on tissue regenerative medicine over the past few decades.
Tissue repair and regeneration is a complex and dynamic physiological process subdivided into four coordinated, continuous, and overlapping stages: hemostasis, inflammation, hyperplasia, and remodeling. Stem cells can be involved in this process, and stem-cell therapy is currently being given the utmost research importance. With the development of regenerative medicine, stem cell transplantation has been considered as a viable option to treat various refractory clinical diseases. These cells have great therapeutic potential due to their ability to self-replicate, differentiate, and regulate hematopoietic and immune cells. For example, osteoblastic differentiation is a vital process during bone remodeling and fracture healing, and is regulated by an array of biological factors. Mesenchymal stem cells (MSCs) are capable to be stimulated towards osteoblasts, and are the main healing-promoting cell type in fracture healing. In addition, MSCs are a kind of precursor cell with a series of therapeutic molecules, with the ability to respond to the surrounding microenvironment. Moreover, MSCs can regulate their own fate and behavior by sensing the surrounding microenvironment for indicators such as inflammation, infection, or tissue damage.
In this Research Topic, we aim to collect original research and review articles that will improve our understanding on the regenerative mechanisms of multiple tissues damaged by trauma, such as bone, muscle, cartilage, and skin. In addition, we welcome original research investigating the importance of the communication between physical stimulus and stem cells in the application of tissue repair strategies.
Potential topics include but are not limited to the following:
1. Stem cells-based treatments for tissue regeneration
2. The role of cytokines, chemokines, and exosomes in stem cell-based transplantation and therapeutics in tissue repair and regeneration
3. Mechanism of stem cell therapy regulated by immune system
4. Novel molecular mechanisms, mechanical stimuli, and biomaterial design for the directional differentiation of stem cells in vivo and in vitro
5. Stem cells interactions with the microenvironment in physiological and pathological conditions
6. Identity and subpopulation of novel stem cells
7. Application of mesenchymal stem cell-based therapy (extracted from bone marrow, adipose tissue, placenta, or other organs) for tissue repair and regeneration
8. System review of stem cells and stem cell-based biomaterials in the application of tissue regeneration
