About this Research Topic
Chronic infections are infections that fail to be treated in a certain period and so become persistent and latent infections, resulting in mobility and mortality of the patients. Common chronic infections include chronic wound infection, osteomyelitis, chronic lung infection in cystic fibrosis patients and chronic obstructive pulmonary disease, chronic tuberculosis, chronic otitis media, chronic rhinosinusitis, chronic oral infections (dental caries, gingivitis, periodontitis), chronic urinary tract infections and other medical device associated chronic infections, chronic fungal infections, and persistent viral infections.
The microbial communities responsible for chronic infections can be composed of a single species or multiple species; this can include bacteria, viruses, and fungi, or a mix of all. The mechanisms of chronic infections are still poorly understood. Improving our understanding of the molecular basis of chronic infections in both host and pathogen will facilitate strategies for early intervention and targeted therapeutic strategies.
Through this topic, we aim to increase our knowledge of the molecular basis of chronic infections, the microbial community and their virulence and pathogenicity, host-pathogen interaction network, microbial and host transcriptome, protein-protein interactions and metabolome present in chronic infections.
This Research Topic welcomes manuscripts on the following, but not limited to, subthemes:
1.) Metagenomics to investigate microbial functions, virulence and pathogenicity
2.) Metatranscriptomics to investigate gene expression of microbial community
3.) Host transcriptome in chronic infections development and progression
4.) Host-pathogen interaction network
5.) Microbial and host protein-protein interaction
Please consider the quality and content requirements for experimental studies as outlined below:
Systems Microbiology does not consider descriptive studies that are solely based on amplicon (eg. 16S rRNA) profiles, unless they are accompanied by a clear hypothesis and experimentation and provide insight into the microbiological system or process being studied.
The microbial communities responsible for chronic infections can be composed of a single species or multiple species; this can include bacteria, viruses, and fungi, or a mix of all. The mechanisms of chronic infections are still poorly understood. Improving our understanding of the molecular basis of chronic infections in both host and pathogen will facilitate strategies for early intervention and targeted therapeutic strategies.
Through this topic, we aim to increase our knowledge of the molecular basis of chronic infections, the microbial community and their virulence and pathogenicity, host-pathogen interaction network, microbial and host transcriptome, protein-protein interactions and metabolome present in chronic infections.
This Research Topic welcomes manuscripts on the following, but not limited to, subthemes:
1.) Metagenomics to investigate microbial functions, virulence and pathogenicity
2.) Metatranscriptomics to investigate gene expression of microbial community
3.) Host transcriptome in chronic infections development and progression
4.) Host-pathogen interaction network
5.) Microbial and host protein-protein interaction
Please consider the quality and content requirements for experimental studies as outlined below:
Systems Microbiology does not consider descriptive studies that are solely based on amplicon (eg. 16S rRNA) profiles, unless they are accompanied by a clear hypothesis and experimentation and provide insight into the microbiological system or process being studied.
Keywords: metagenomics, metatranscriptomics, host-pathogen interactions, protein-protein interactions, metabolome, Chronic Infection, Host Response, Microbiome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
