About this Research Topic
There is a growing rise in the burden of liver disease, highlighting the pressing need to find therapies to prevent liver disease progression. Cirrhosis is a leading cause of liver-related death and is currently the 11th most common cause of death globally, with disease progression leading to complications such as portal hypertension, cancer and death. This continuing increase in the burden of liver disease is in stark contrast to the vast improvements made in health and life expectancy for most chronic disorders and most cancers. Improved understanding of disease pathogenesis and discovery of novel modalities of treatment to prevent or halt liver disease progression remain significant unmet needs. With this Research Topic, we aim to focus on updating ‘state of the art’ knowledge of the pathogenesis of a variety of liver diseases, which will inform novel therapies. Additionally, the series will encompass articles on novel agents currently in clinical trials with a potential to be used as future therapies in liver diseases. The main contributors to global liver disease burden including autoimmune and cholestatic liver diseases, viral hepatitis, NAFLD/NASH, alcohol-related liver disease, cirrhosis/ portal hypertension and Wilson’s/metabolic diseases will be covered.
We welcome the submission of Original Research, review, mini-review and clinical trial articles.
We welcome the submission of Original Research, review, mini-review and clinical trial articles.
Keywords: Therapeutic Targets, Liver Disease, viral hepatitis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
