Insights in Experimental Pharmacology and Drug Discovery: 2021

Editorial

28 February 2022

Editorial: Insights in Experimental Pharmacology and Drug Discovery: 2021

Andres Trostchansky

and

Salvatore Salomone

4,246 views

1 citations

Editors

Salvatore Salomone

University of Catania

Andrés Trostchansky

Facultad de Medicina, Universidad de la República

Impact

Effect of BSS on immunohistochemistry of CD31, VEGFR2, and P-VEGFR2 on experimental arthritis. (A) CD31 immunohistochemical staining of the ankle joints in each group, and the optical density value (B) analysis using ImageJ (n = 6) (×200, scale bar = 50 μm). (C) VEGFR2 immunohistochemical staining of the ankle joints in each group, and the optical density value (D) analysis using ImageJ (n = 6) (×200, scale bar = 50 μm). (E) p-VEGFR2 immunohistochemical staining of the ankle joints in each group, and (F) the optical density value analysis using ImageJ (n = 6) (×200, scale bar = 50 μm). All data are shown as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, n.s. = not significant.

Original Research

28 February 2022

β-Sitosterol Inhibits Rheumatoid Synovial Angiogenesis Through Suppressing VEGF Signaling Pathway

Kai Qian

, 7 more and

Chang-Song Lin

5,304 views

34 citations

Molecular docking shows specific binding of apigenin to ERα within the E2-ligand binding domain. Images showing the binding site of apigenin (A), E2 (B), and lentinan (C) in ERα. (D) Interaction of amino acid residues located in the ligand binding domain (LBD) of ERα. (E) Binding energy of apigenin, E2, and lentinan with ERα.

Original Research

21 February 2022

Apigenin, a Single Active Component of Herbal Extract, Alleviates Xerostomia via ERα-Mediated Upregulation of AQP5 Activation

Wei Wei

, 7 more and

Jiang Li

5,119 views

11 citations

Original Research

17 February 2022

Levistilide A Promotes Expansion of Human Umbilical Cord Blood Hematopoietic Stem Cells by Enhancing Antioxidant Activity

Mei He

, 13 more and

Quan Zhang

3,346 views

5 citations

Brief Research Report

24 December 2021

Antioxidant Activity of Fluoxetine and Vortioxetine in a Non-Transgenic Animal Model of Alzheimer’s Disease

Giuseppe Caruso

, 12 more and

Filippo Caraci

7,416 views

33 citations

Original Research

16 November 2021

Antinociceptive and Antipruritic Effects of HSK21542, a Peripherally-Restricted Kappa Opioid Receptor Agonist, in Animal Models of Pain and Itch

Xin Wang

, 11 more and

Jia Ni

5,022 views

20 citations

Original Research

06 December 2021

Protective Effects and Mechanisms of Polyethylene Glycol Loxenatide Against Hyperglycemia and Liver Injury in db/db diabetic Mice

Yu Zhang

, 5 more and

Chen Shi

4,309 views

12 citations

Original Research

03 January 2022

Precision Medicine in Alzheimer’s Disease: Investigating Comorbid Common Biological Substrates in the Rat Model of Amyloid Beta-Induced Toxicity

Maria Grazia Morgese

, 9 more and

Luigia Trabace

2,905 views

13 citations

Original Research

02 February 2022

Blimp-1 Upregulation by Multiple Ligands via EGFR Transactivation Inhibits Cell Migration in Keratinocytes and Squamous Cell Carcinoma

Hyemin Lee

, 5 more and

Wan-Wan Lin

3,376 views

3 citations

Review

03 November 2021

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

Shejuti Rahman Brishty

, 4 more and

S. M. Abdur Rahman

22,026 views

91 citations

Review

15 October 2021

Bioactivities and Structure–Activity Relationships of Fusidic Acid Derivatives: A Review

Junjun Long

, 3 more and

Yi Bi

6,324 views

24 citations

Original Research

30 August 2021

α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway

Xiuzhi Zhu

, 5 more and

Jin-Zhang Zeng

4,385 views

28 citations

Original Research

08 October 2021

Berberine and Its Main Metabolite Berberrubine Inhibit Platelet Activation Through Suppressing the Class I PI3Kβ/Rasa3/Rap1 Pathway

Can Wang

, 7 more and

Weijia Kong

4,645 views

21 citations

Original Research

21 October 2021

Photodynamic Therapy of Novel Photosensitizer Ameliorates TNBS-Induced Ulcerative Colitis via Inhibition of AOC1

Yumei Rong

, 4 more and

Tianjun Liu

3,608 views

12 citations

Original Research

06 October 2021

The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling

Annamaria Fidilio

, 12 more and

Carmela Parenti

2,473 views

13 citations

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