To deal with the increasing environmental deterioration and energy shortage, various value-added products including bulk chemicals and bio-fuels have been produced by microbial fermentation from waste-based feedstocks industrially, instead of by the traditional chemical processing from crude oil. However, microorganisms usually encounter various environmental stress during the process of fermentation, which always causes disturbance to the growth and metabolism of the cells. On some occasions when the pressure is not strong, microorganisms could evolve and adapt to the environmental stress, and even develop enhanced tolerance to stress. In view of this, the understanding of the mechanism below this is crucial for direct modification of microbial microbes for specific stress. More important, microorganisms with strong tolerance to environmental stress either from evolution or direct modification are desired for higher productivity.
The Research Topic aims to publish novel research contributions on the identification of mechanisms underlying the stress adaptative strains, development of technologies for improvement of the stress tolerance microbes, metabolic engineering of microorganisms for improved production of value-added chemicals, and the applications of the stress tolerant strains under various conditions with focusing on microbes with improved robustness toward toxic or inhibitory substrates or products. In the meanwhile, the application of waste-based feedstocks via innovative approaches towards achieving an efficient and productive biosynthetic future is encouraged.
• Identification of genetic, transcriptional, metabolic and physiological mechanisms underlying the stress adaptative strains or the synthetic tolerance strains.
• Dynamic regulation, rewiring or reprogram the metabolic flux to enhance the robustness toward toxic or inhibitory substrates or products while improving productivity of value-added chemicals.
• Development of toolkits (including genetic exploration, identification and transformation methods) enabling rapid building of engineered cells for improved robustness toward inhibitors in basic research and industrial biotechnology.
• Use of random or semi-rational strategies such as directed evolution, genetic engineering, and adaptive evolution strategies to improve the tolerance of microbial cells against the stress in the process of biological manufacturing.
• Utilization of waste-based feedstocks with inhibitory substances by stress tolerant microorganisms for enhanced production of industrially relevant bio-based products (e.g., lipids, organic acids, ethanol, etc.,).
Please note that tolerance engineering needs to focus on developing microbes with improved robustness toward toxic or inhibitory substrates or products.
To deal with the increasing environmental deterioration and energy shortage, various value-added products including bulk chemicals and bio-fuels have been produced by microbial fermentation from waste-based feedstocks industrially, instead of by the traditional chemical processing from crude oil. However, microorganisms usually encounter various environmental stress during the process of fermentation, which always causes disturbance to the growth and metabolism of the cells. On some occasions when the pressure is not strong, microorganisms could evolve and adapt to the environmental stress, and even develop enhanced tolerance to stress. In view of this, the understanding of the mechanism below this is crucial for direct modification of microbial microbes for specific stress. More important, microorganisms with strong tolerance to environmental stress either from evolution or direct modification are desired for higher productivity.
The Research Topic aims to publish novel research contributions on the identification of mechanisms underlying the stress adaptative strains, development of technologies for improvement of the stress tolerance microbes, metabolic engineering of microorganisms for improved production of value-added chemicals, and the applications of the stress tolerant strains under various conditions with focusing on microbes with improved robustness toward toxic or inhibitory substrates or products. In the meanwhile, the application of waste-based feedstocks via innovative approaches towards achieving an efficient and productive biosynthetic future is encouraged.
• Identification of genetic, transcriptional, metabolic and physiological mechanisms underlying the stress adaptative strains or the synthetic tolerance strains.
• Dynamic regulation, rewiring or reprogram the metabolic flux to enhance the robustness toward toxic or inhibitory substrates or products while improving productivity of value-added chemicals.
• Development of toolkits (including genetic exploration, identification and transformation methods) enabling rapid building of engineered cells for improved robustness toward inhibitors in basic research and industrial biotechnology.
• Use of random or semi-rational strategies such as directed evolution, genetic engineering, and adaptive evolution strategies to improve the tolerance of microbial cells against the stress in the process of biological manufacturing.
• Utilization of waste-based feedstocks with inhibitory substances by stress tolerant microorganisms for enhanced production of industrially relevant bio-based products (e.g., lipids, organic acids, ethanol, etc.,).
Please note that tolerance engineering needs to focus on developing microbes with improved robustness toward toxic or inhibitory substrates or products.
