DNA damage affects all major cellular processes. Investigation of the impact of DNA damage on disease has dramatically expanded over the past few decades. The DNA damage response and DNA repair pathways were predominantly examined in the framework of cancer investigation. Lessons learned from the biology of DNA damage repair generated therapeutic opportunities that were successfully implemented in clinical oncology. Besides cancer, DNA damage takes also a heavy toll on other biological systems, including aging, reproduction, and the endocrine system. Dissecting the mechanisms that are responsible for the DNA damage response in endocrine organs as well as identification of the cellular mediators involved in these defense paths are important novel areas in the broad field of Endocrinology.
The availability of global analytical platforms has transformed both basic and clinical research at an unprecedented speed. The purpose of this Frontiers in Endocrinology Research Topic is to provide a comprehensive, yet highly focused, state-of-the-art overview of current trends and approaches in the analysis of DNA damage in the specific context of endocrinology. This Article Collection is expected to provide the setting for a fresh inquiry into the impact of DNA damage on endocrine function. Analyses will shed light on mechanistic aspects and endocrine roles of DNA damage sensors such as p53, BRCA1, ATM, and others. Despite its major translational relevance, this topic has not yet been addressed in a systematic fashion.
The main theme of this Research Topic is the impact of DNA damage on endocrine function. Particular attention will be given to the role and regulation of DNA damage sensors (e.g., p53, BRCA1, ATM) in the pituitary, adrenal, thyroid, ovary, etc.
The Topic Editors welcome the submission of different kinds of articles (original research articles, reviews, etc) and clinical papers are highly encouraged.
The Research Topic is aimed at both basic scientists and clinicians.
DNA damage affects all major cellular processes. Investigation of the impact of DNA damage on disease has dramatically expanded over the past few decades. The DNA damage response and DNA repair pathways were predominantly examined in the framework of cancer investigation. Lessons learned from the biology of DNA damage repair generated therapeutic opportunities that were successfully implemented in clinical oncology. Besides cancer, DNA damage takes also a heavy toll on other biological systems, including aging, reproduction, and the endocrine system. Dissecting the mechanisms that are responsible for the DNA damage response in endocrine organs as well as identification of the cellular mediators involved in these defense paths are important novel areas in the broad field of Endocrinology.
The availability of global analytical platforms has transformed both basic and clinical research at an unprecedented speed. The purpose of this Frontiers in Endocrinology Research Topic is to provide a comprehensive, yet highly focused, state-of-the-art overview of current trends and approaches in the analysis of DNA damage in the specific context of endocrinology. This Article Collection is expected to provide the setting for a fresh inquiry into the impact of DNA damage on endocrine function. Analyses will shed light on mechanistic aspects and endocrine roles of DNA damage sensors such as p53, BRCA1, ATM, and others. Despite its major translational relevance, this topic has not yet been addressed in a systematic fashion.
The main theme of this Research Topic is the impact of DNA damage on endocrine function. Particular attention will be given to the role and regulation of DNA damage sensors (e.g., p53, BRCA1, ATM) in the pituitary, adrenal, thyroid, ovary, etc.
The Topic Editors welcome the submission of different kinds of articles (original research articles, reviews, etc) and clinical papers are highly encouraged.
The Research Topic is aimed at both basic scientists and clinicians.
