Extracellular Vesicles in Diseases, Host-pathogen Interaction and Therapeutic Applications

Editorial

22 September 2022

Editorial: Extracellular vesicles in diseases, host-pathogen interaction and therapeutic applications

Lysangela R. Alves

Alejandro Correa

Allan J. Guimarães

and

Marcio L. Rodrigues

1,630 views

0 citations

Editors

Lysangela Ronalte Alves

Carlos Chagas Institute (ICC), Oswaldo Cruz Foundation

Alejandro Correa

Carlos Chagas Institute (ICC), Oswaldo Cruz Foundation

Allan J. Guimarães

Fluminense Federal University

Marcio L. Rodrigues

Oswaldo Cruz Foundation (Fiocruz)

Impact

I. Small non-coding RNAs and proteins in the serum EVs of patients with sepsis and ARDS can be used as diagnostic markers. II. EVs could be engineered and employed as drug delivery vehicles for downstream treatment via two different ways: incubate the drugs with the cells to produce drugs-loaded EVs and engineer the genetic characteristics of cells through genetic remodeling, making EVs with designed bio-active cargoes.

Review

07 April 2022

Extracellular Vesicles, New Players in Sepsis and Acute Respiratory Distress Syndrome

Wenqiang Jing

, 2 more and

Wei Yan

5,128 views

9 citations

The graphics show the EV particle concentration (particles/ml) relative to the particle diameter (nm).

Original Research

28 February 2022

Extracellular Vesicles From Paracoccidioides brasiliensis Can Induce the Expression of Fungal Virulence Traits In Vitro and Enhance Infection in Mice

Carla Elizabete Octaviano

, 1 more and

Rosana Puccia

3,171 views

12 citations

Original Research

18 August 2022

Human endothelial cell-derived exosomal microRNA-99a/b drives a sustained inflammatory response during sepsis by inhibiting mTOR expression

Glenn Fitzpatrick

, 4 more and

Steven W. Kerrigan

3,227 views

11 citations

Review

04 July 2022

Diagnostic and Therapeutic Properties of Exosomes in Cardiac Fibrosis

Jiwen Fan

, 1 more and

Yuquan He

3,647 views

7 citations

Proteomic analyses of 2D and 3D MSC-derived extracellular vesicles (EVs). (A) Venn diagram displaying number of proteins identified in EVs and donor cells grown in 2D and 3D condition using label free-based mass spectrometry from each group. (B) principal component analysis of EVs and donor cells grown in 2D and 3D condition. (C) Balloon plot displaying Gene Ontology cellular component enrichment terms of EV vs cells in each condition (Benjamin-Hochberg FDR<0.05). (D) Venn diagram displaying number of proteins identified in EVs from each group compared to exosome/EV database, ExoCarta (top 100 abundant proteins). (E) Volcano plot displaying differential protein expression of EVs derived from 2D and 3D growth condition. (F) Balloon plot displaying g:Profiler enrichment terms (Reactome, KEGG pathways, Gene Ontology: biological process, molecular function, cellular component) in EVs from each group (p < 0.05). Left panel: “immune-based associated function,” right panel: “fibrosis-related function”.

Original Research

14 February 2022

Effect of 2D and 3D Culture Microenvironments on Mesenchymal Stem Cell-Derived Extracellular Vesicles Potencies

Gina D. Kusuma

, 9 more and

Rebecca Lim

12,885 views

54 citations

APP overexpression inhibits miR-185-5p sorting to exosomes via the direct interaction between APP 3′UTR and miR-185-5p. (A) The numbers of APP-targeting miRNAs and down-regulated miRNAs in APP-EXO were shown in the Venn diagram. The overlapping miRNAs were listed. (B) The readcounts of five overlapping miRNAs in EXO were ranked from more to less. (C) The fold changes of five overlapping miRNAs between APP-EXO and EXO were ranked from more to less. (D) The down-regulation of miR-185-5p in APP-EXO was determined by RT-qPCR. (E) The down-regulation of miR-185-5p in AD-EXO was determined by RT-qPCR. (F) Repression of luciferase activities by the APP 3′UTR were dependent on miR-185-5p. Firefly luciferase activities were normalized to the internal control, Renilla luciferase activities. (G) The down-regulation of miR-185-5p in UTR-EXO, but not CDS-EXO, was confirmed by RT-qPCR. Data were represented as mean ± s. d. from three independent experiments. *, **, ***, and **** denote p < 0.05, p < 0.01, p < 0.001, and p < 0.0001, respectively. ns denotes no significance.

Original Research

11 February 2022

Exosomes Mediate APP Dysregulation via APP-miR-185-5p Axis

Lu Ding

, 10 more and

Jialin C. Zheng

4,772 views

25 citations

Review

20 December 2021

Extracellular Vesicles: Potential Role in Remote Signaling and Inflammation in Trypanosoma cruzi-Triggered Disease

Luíza Dantas-Pereira

, 1 more and

Joseli Lannes-Vieira

3,532 views

14 citations

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