Protein kinases that share the ability to readily phosphorylate casein in vitro have been historically denoted by the conventional term 'casein kinases'. Apart from this common feature, however, these “casein kinases” namely protein kinases CK1 (casein kinases 1, CKI) and CK2 (casein kinase CK2, CKII), and the “genuine” Golgi apparatus casein kinase (G-CK/Fam20C), are quite unrelated to each other. Noteworthy, casein kinases alone account for the generation of a large proportion of the human phosphoproteome including almost the whole phosphosecretome. Such an extraordinary pleiotropicity accounts for the dramatic consequences observed upon dysregulation of these enzymes. Indeed, all casein kinases have been reported to be implicated in several pathologies, including cancer, neurodegenerative disorders, viral and parasite infections, and biomineralization diseases. Therefore, the tuning of casein kinases is considered instrumental to counteract many pathological conditions and their targeting has attracted the attention of many research groups and companies.
Over the past decades, the interest in casein kinases has constantly grown as demonstrated by the huge number of papers published on this topic. Nevertheless, ever-new aspects related to the pathophysiology of this group of enzymes are continuously emerging. With this Research Topic, we would like to create a forum where researchers can share with the scientific community their latest discoveries and circulate their reviews on different aspects of the casein kinases research field. In particular, special attention will be devoted to topics that might generate a breakthrough into the understanding of the roles of casein kinases in pathological conditions exploiting multidisciplinary approaches.
This Research Topic aims to assemble Original Research Articles, Reviews, Mini Reviews, and Perspectives that highlight the latest advances of research on casein kinases and the implications of these discoveries for human health. Areas of interest will include, among others, the following:
• Therapeutical opportunities associated with casein kinases modulation
• Mechanistic aspects underlying the implication of casein kinases in human diseases
• Structural aspects of casein kinases functionality and interactions
• Development of novel theragnostic strategies.
Protein kinases that share the ability to readily phosphorylate casein in vitro have been historically denoted by the conventional term 'casein kinases'. Apart from this common feature, however, these “casein kinases” namely protein kinases CK1 (casein kinases 1, CKI) and CK2 (casein kinase CK2, CKII), and the “genuine” Golgi apparatus casein kinase (G-CK/Fam20C), are quite unrelated to each other. Noteworthy, casein kinases alone account for the generation of a large proportion of the human phosphoproteome including almost the whole phosphosecretome. Such an extraordinary pleiotropicity accounts for the dramatic consequences observed upon dysregulation of these enzymes. Indeed, all casein kinases have been reported to be implicated in several pathologies, including cancer, neurodegenerative disorders, viral and parasite infections, and biomineralization diseases. Therefore, the tuning of casein kinases is considered instrumental to counteract many pathological conditions and their targeting has attracted the attention of many research groups and companies.
Over the past decades, the interest in casein kinases has constantly grown as demonstrated by the huge number of papers published on this topic. Nevertheless, ever-new aspects related to the pathophysiology of this group of enzymes are continuously emerging. With this Research Topic, we would like to create a forum where researchers can share with the scientific community their latest discoveries and circulate their reviews on different aspects of the casein kinases research field. In particular, special attention will be devoted to topics that might generate a breakthrough into the understanding of the roles of casein kinases in pathological conditions exploiting multidisciplinary approaches.
This Research Topic aims to assemble Original Research Articles, Reviews, Mini Reviews, and Perspectives that highlight the latest advances of research on casein kinases and the implications of these discoveries for human health. Areas of interest will include, among others, the following:
• Therapeutical opportunities associated with casein kinases modulation
• Mechanistic aspects underlying the implication of casein kinases in human diseases
• Structural aspects of casein kinases functionality and interactions
• Development of novel theragnostic strategies.
