Worldwide, obesity and metabolic diseases, such as nonalcoholic fatty liver disease and type 2 diabetes, have become the primary threat to human health, and the development of those diseases indicates the disorder of glucose and lipid metabolism in the body. Emerging studies have shown that nutrient metabolism and the physiological and pathological status of the host are closely related to the intestinal microbiome and its metabolites. The intestinal microbiota is the moderator connecting the diet and host metabolism, and the plant polysaccharides (PS) with potential prebiotics activity are the main factors regulating the abundance and composition of the intestinal microbiota. The starch utilization-like systems (Sus) in the outer membrane of bacteria can specifically recognize and bind to certain plant-derived PS. Thus, PSs from different plants can specially shape different types of the gut microbial community, and produce differentiated metabolites, which interferes with the physiological and pathological processes of the host. Clarifying the structure, bioactivities, and mechanism by which PS modulates the occurrence of obesity and metabolic disease is thus critical for applying natural PSs in pharmaceutical and functional food.
Research on molecular structure and omics/biological mechanism of plant-derived polysaccharides (PS) is an interdisciplinary field. The plant-derived PS is a kind of functional food exerting a wide variety of bioactivities, such as antioxidants, anti-inflammation, and immunomodulation. Especially, PS has a positive therapeutic effect on metabolic diseases including obesity, non-alcoholic fatty liver, and diabetes by remodeling the intestinal microbiome and metabolome, thereby regulating the glucose and lipid metabolism of the host. The goal of this Research Topic is to present the latest scientific discoveries and expand the integration of different disciplines, and thus providing the scientific reference for applying natural PSs in pharmaceutical and functional food.
We welcome submissions of different types of manuscripts including Original Research papers, Reviews, and Methods, including but not limited to:
• The structural features and bioactivities of plant-derived polysaccharide (PS) as the source of functional food;
• The effects of plant-derived PS on the (gut) microbiome and metabolome of human and other model animals (in vivo & in vitro);
• The mechanisms of phytogenic PSs modulating the metabolism and differentiation of tissue/adipose cells (in vitro);
• The mechanism of plant-derived PS intervening in the obesity and metabolic disease of hosts (humans or model animals).
Worldwide, obesity and metabolic diseases, such as nonalcoholic fatty liver disease and type 2 diabetes, have become the primary threat to human health, and the development of those diseases indicates the disorder of glucose and lipid metabolism in the body. Emerging studies have shown that nutrient metabolism and the physiological and pathological status of the host are closely related to the intestinal microbiome and its metabolites. The intestinal microbiota is the moderator connecting the diet and host metabolism, and the plant polysaccharides (PS) with potential prebiotics activity are the main factors regulating the abundance and composition of the intestinal microbiota. The starch utilization-like systems (Sus) in the outer membrane of bacteria can specifically recognize and bind to certain plant-derived PS. Thus, PSs from different plants can specially shape different types of the gut microbial community, and produce differentiated metabolites, which interferes with the physiological and pathological processes of the host. Clarifying the structure, bioactivities, and mechanism by which PS modulates the occurrence of obesity and metabolic disease is thus critical for applying natural PSs in pharmaceutical and functional food.
Research on molecular structure and omics/biological mechanism of plant-derived polysaccharides (PS) is an interdisciplinary field. The plant-derived PS is a kind of functional food exerting a wide variety of bioactivities, such as antioxidants, anti-inflammation, and immunomodulation. Especially, PS has a positive therapeutic effect on metabolic diseases including obesity, non-alcoholic fatty liver, and diabetes by remodeling the intestinal microbiome and metabolome, thereby regulating the glucose and lipid metabolism of the host. The goal of this Research Topic is to present the latest scientific discoveries and expand the integration of different disciplines, and thus providing the scientific reference for applying natural PSs in pharmaceutical and functional food.
We welcome submissions of different types of manuscripts including Original Research papers, Reviews, and Methods, including but not limited to:
• The structural features and bioactivities of plant-derived polysaccharide (PS) as the source of functional food;
• The effects of plant-derived PS on the (gut) microbiome and metabolome of human and other model animals (in vivo & in vitro);
• The mechanisms of phytogenic PSs modulating the metabolism and differentiation of tissue/adipose cells (in vitro);
• The mechanism of plant-derived PS intervening in the obesity and metabolic disease of hosts (humans or model animals).
