Thromboinflammation, the coordinated activation of inflammatory and thrombotic responses is prevalent across a range of diseases. Broadly, thromboinflammation encompasses processes which initiate endothelial dysfunction impairing their antithrombotic and anti-inflammatory functions which propagates coagulation dysregulation, complement and platelet activation, and subsequent leukocyte recruitment to the vasculature.
Thromboinflammation is common in vascular disorders including atherosclerosis, stroke and deep vein thrombosis, in addition to infectious diseases (e.g. sepsis), and viral infections (e.g. COVID-19). Risk of thromboinflammation, and adverse clinical outcomes are hypothesized to be amplified by underlying metabolic and inflammatory disorders (e.g. diabetes, obesity, systemic lupus erythematosus.
This review series aims to highlight prominent and emerging relationships between platelets, innate immune cells, and the endothelium and their role in the regulation of thromboinflammatory responses in sterile and infectious diseases. Additionally, this series seeks to include articles that consider current and potential clinical therapeutic options to prevent or treat thromboinflammation.
Thromboinflammation, the coordinated activation of inflammatory and thrombotic responses is prevalent across a range of diseases. Broadly, thromboinflammation encompasses processes which initiate endothelial dysfunction impairing their antithrombotic and anti-inflammatory functions which propagates coagulation dysregulation, complement and platelet activation, and subsequent leukocyte recruitment to the vasculature.
Thromboinflammation is common in vascular disorders including atherosclerosis, stroke and deep vein thrombosis, in addition to infectious diseases (e.g. sepsis), and viral infections (e.g. COVID-19). Risk of thromboinflammation, and adverse clinical outcomes are hypothesized to be amplified by underlying metabolic and inflammatory disorders (e.g. diabetes, obesity, systemic lupus erythematosus.
This review series aims to highlight prominent and emerging relationships between platelets, innate immune cells, and the endothelium and their role in the regulation of thromboinflammatory responses in sterile and infectious diseases. Additionally, this series seeks to include articles that consider current and potential clinical therapeutic options to prevent or treat thromboinflammation.
