The development, remodeling and regeneration of craniofacial tissues or organs are complex processes, and dysregulation of these processes can cause various craniofacial disorders. The physiological processes of craniofacial tissues development, remodeling and regeneration are driven by dynamic regulation and controlled by a network of specific genes. Epigenetic machineries such as DNA and histone modifying enzymes and noncoding RNAs (ncRNAs) have been identified as important contributors in cell biology. Furthermore, various stem cells play a key role in the growth, regeneration, and repair of craniofacial tissues. Thus, discovering the epigenetic regulatory mechanisms of stem cells derived from craniofacial tissues will aid in understanding the processes of craniofacial tissues development, remodeling and regeneration, and facilitate the development of novel therapies for craniofacial tissue repair.
The goal of this Research Topic is to:
- Investigate and explore the novel epigenetic regulatory mechanisms which play an important role in the function regulation of stem cells derived from craniofacial tissues.
- Review the latest research into the epigenetic regulatory mechanisms which are involved in the regulation of stem cells derived from craniofacial tissues
- Showcase and provide commentary on new discoveries within this field
The types of manuscripts we are interested in include Original Research, Reviews and Mini Reviews, Case Reports, Letters and Commentary.
Specific themes include:
1, The novel regulatory mechanisms of DNA methylation and RNA methylation which are involved in the differentiation, proliferation, migration, and immunoregulation of stem cells derived from craniofacial tissues and craniofacial development.
2, The novel regulatory mechanisms of histone modification including methylation, acetylation, etc which are involved in the differentiation, proliferation, migration, and immunoregulation of stem cells derived from craniofacial tissues and craniofacial development.
3, The novel regulatory mechanisms of non-coding RNA including miRNA, lncRNA and ceRNA, etc which are involved in the differentiation, proliferation, migration, and immunoregulation of stem cells derived from craniofacial tissues and craniofacial development.
4, Other epigenetic regulatory mechanisms which are involved in the regulation of stem cells derived from craniofacial tissues and craniofacial development.