The immune system provides surveillance against pathogens and tumors, but can also drive autoimmune and autoinflammatory conditions when improperly activated. Understanding the mechanisms that underlie these conditions requires examination of both the immune response and the involved tissues themselves. The skin is easily observed and sampled, providing important insights into these processes. Immune-stromal interactions are starting to be well-characterized in skin diseases, including neuro-immune interactions, keratinocyte – immune cells interactions, and macrophage - fibroblast crosstalk in inflammatory fibrosing disorders.
The goal of this collection is to feature cutting-edge research describing immune-stromal interactions that underlie the pathogeneses of skin diseases.
We welcome submissions of Original Research and Review articles addressing, but not limited, to the following aspects:
- Role and mechanisms of keratinocytes, fibroblasts, neurons, blood vessels, and other stromal skin populations in autoinflammatory/autoimmune skin disorders
- Role and mechanisms of immune cell-stromal cell crosstalk, such as the impact of cytokines or chemokines on stromal cell signaling & function
- Role and mechanisms of maintenance of immune cells in skin tissue, such as resident memory T and/or B cell maintenance by skin-specific factors
- Role and mechanisms of antigen presentation by classical and nonclassical antigen presenting cells in autoimmune skin diseases, such as keratinocytes
Dr. Jillian Richmond is an inventor on patent application #15/851,651, “Anti-human CXCR3 antibodies for the Treatment of Vitiligo” which covers targeting CXCR3 for the treatment of vitiligo; and on patent #62489191, “Diagnosis and Treatment of Vitiligo” which covers targeting IL-15 and Trm for the treatment of vitiligo. The other Topic Editors declare no competing interests with regards to the Research Topic theme.
The immune system provides surveillance against pathogens and tumors, but can also drive autoimmune and autoinflammatory conditions when improperly activated. Understanding the mechanisms that underlie these conditions requires examination of both the immune response and the involved tissues themselves. The skin is easily observed and sampled, providing important insights into these processes. Immune-stromal interactions are starting to be well-characterized in skin diseases, including neuro-immune interactions, keratinocyte – immune cells interactions, and macrophage - fibroblast crosstalk in inflammatory fibrosing disorders.
The goal of this collection is to feature cutting-edge research describing immune-stromal interactions that underlie the pathogeneses of skin diseases.
We welcome submissions of Original Research and Review articles addressing, but not limited, to the following aspects:
- Role and mechanisms of keratinocytes, fibroblasts, neurons, blood vessels, and other stromal skin populations in autoinflammatory/autoimmune skin disorders
- Role and mechanisms of immune cell-stromal cell crosstalk, such as the impact of cytokines or chemokines on stromal cell signaling & function
- Role and mechanisms of maintenance of immune cells in skin tissue, such as resident memory T and/or B cell maintenance by skin-specific factors
- Role and mechanisms of antigen presentation by classical and nonclassical antigen presenting cells in autoimmune skin diseases, such as keratinocytes
Dr. Jillian Richmond is an inventor on patent application #15/851,651, “Anti-human CXCR3 antibodies for the Treatment of Vitiligo” which covers targeting CXCR3 for the treatment of vitiligo; and on patent #62489191, “Diagnosis and Treatment of Vitiligo” which covers targeting IL-15 and Trm for the treatment of vitiligo. The other Topic Editors declare no competing interests with regards to the Research Topic theme.
