Animal-human interaction, in association with the shared environment, poses a significant public health threat. Emerging infectious diseases (EIDs) of animal origin account for more than 70% of human diseases and six out of ten infectious diseases are linked to animals, including influenza, SARS, MERS, and COVID-19 pandemics. Understanding the disease epidemiology, transmission dynamics, and immunopathogenesis will provide insights on the prevention and control of such diseases, at the animal-human-environment interface. The mechanisms of immune competence, immune evasion, immune amnesia, and immune-prophylaxis are hallmarks of basic/applied research and interventions with regards to the immunopathology of diseases. We believe that this Research Topic will make a valuable contribution to the understanding of zoonotic pathogens, contagion properties, spread, immunopathogenesis, and the prevention of viral zoonoses.
An understanding of disease mechanisms at cellular and molecular levels is needed. The boosting of host immune responses and provision of sustained or effective immunity are key factors in the prevention of microbial infections or diseases. Therefore, the aim of this Research Topic is to recapitulate and collate relevant, recent data regarding zoonotic diseases of global importance and to decipher basic immunopathogenesis mechanisms. Especially now, during the COVID-19 pandemic, it is of utmost importance to explore zoonotic aspects (spillover, transmission dynamics, contagiousness, reservoir hosts), virus-host interactions, and immunogenicity.
This Research Topic aims to cover basic and applied aspects of zoonotic diseases, with a special focus on viral human diseases and their immunopathogeneses. We especially aim to cover:
• Molecular epidemiology of zoonotic viral infections (e.g., Influenza, SARS, MERS and COVID-19) of public or global health importance;
• The evolution and adaptation of zoonotic viruses, in the context of One Health;
• Receptor-mediated spillover events and zoonotic potential of the Influenza, SARS, MERS and SARS-CoV-2 viruses;
• Tissue tropisms and inter-species jump of Influenza, SARS, MERS, and SARS-CoV-2 viruses;
• Immunopathogenesis (host-pathogen interaction), immuno-surveillance and immune evasion of viral infections.
The following article types are welcome: Original research, Review, Mini-Review, Commentary.
Animal-human interaction, in association with the shared environment, poses a significant public health threat. Emerging infectious diseases (EIDs) of animal origin account for more than 70% of human diseases and six out of ten infectious diseases are linked to animals, including influenza, SARS, MERS, and COVID-19 pandemics. Understanding the disease epidemiology, transmission dynamics, and immunopathogenesis will provide insights on the prevention and control of such diseases, at the animal-human-environment interface. The mechanisms of immune competence, immune evasion, immune amnesia, and immune-prophylaxis are hallmarks of basic/applied research and interventions with regards to the immunopathology of diseases. We believe that this Research Topic will make a valuable contribution to the understanding of zoonotic pathogens, contagion properties, spread, immunopathogenesis, and the prevention of viral zoonoses.
An understanding of disease mechanisms at cellular and molecular levels is needed. The boosting of host immune responses and provision of sustained or effective immunity are key factors in the prevention of microbial infections or diseases. Therefore, the aim of this Research Topic is to recapitulate and collate relevant, recent data regarding zoonotic diseases of global importance and to decipher basic immunopathogenesis mechanisms. Especially now, during the COVID-19 pandemic, it is of utmost importance to explore zoonotic aspects (spillover, transmission dynamics, contagiousness, reservoir hosts), virus-host interactions, and immunogenicity.
This Research Topic aims to cover basic and applied aspects of zoonotic diseases, with a special focus on viral human diseases and their immunopathogeneses. We especially aim to cover:
• Molecular epidemiology of zoonotic viral infections (e.g., Influenza, SARS, MERS and COVID-19) of public or global health importance;
• The evolution and adaptation of zoonotic viruses, in the context of One Health;
• Receptor-mediated spillover events and zoonotic potential of the Influenza, SARS, MERS and SARS-CoV-2 viruses;
• Tissue tropisms and inter-species jump of Influenza, SARS, MERS, and SARS-CoV-2 viruses;
• Immunopathogenesis (host-pathogen interaction), immuno-surveillance and immune evasion of viral infections.
The following article types are welcome: Original research, Review, Mini-Review, Commentary.
