Genomic DNA in all types of cells is exposed to insults from endogenous sources, such as oxidative stress, as well as exogenous exposures, including environmental genotoxins and anti-cancer therapeutics. Deficiencies in genome integrity maintenance pathways have been implicated in the etiology of cancer and other disease states. To mitigate the debilitating genomic lesions, cells have evolved many different pathways to sense, repair, and signal in response to such challenges. Research studies focused on understanding genome integrity have utilized a variety of model organisms and cutting-edge technologies (e.g., CRISPR/Cas9, NGS-based genome-wide mapping) at the molecular, cellular, organismal, and ecological levels. Mechanistic studies that help define the process of genome integrity maintenance, the impact of such mechanisms on environmental health, and their role in cancer etiology are highly significant and have led to new ways of diagnosing and treating cancers and other human diseases. Because of the many advances in this area of research over the past few years, this Research Topic intends to provide the latest insights on the field of genome integrity and to discuss the trends of current and future studies aimed at improving our understanding of disease pathogenesis and treatment.
This Research Topic is focused on cutting-edge mechanistic studies of genome integrity, environmental health, and cancer etiology, including but not limited to following topics:
1) DNA damage analysis, DNA damage response pathways and DNA repair mechanisms;
2) DNA recombination and transposons, translesion DNA synthesis, DNA replication and DNA replication stress;
3) Epigenetic regulation of genome integrity;
4) New technologies in the field of genome integrity including next-generation-sequencing (NGS)-based genome wide mapping and profiling of DNA damage and repair;
5) Genetic and/or environmental risk factors for cancer etiology;
6) Environmental exposure, DNA integrity and health.
Robert W. Sobol is a scientific consultant for Canal House Biosciences, LLC. All other co-editors declare no conflicts of interest.
Genomic DNA in all types of cells is exposed to insults from endogenous sources, such as oxidative stress, as well as exogenous exposures, including environmental genotoxins and anti-cancer therapeutics. Deficiencies in genome integrity maintenance pathways have been implicated in the etiology of cancer and other disease states. To mitigate the debilitating genomic lesions, cells have evolved many different pathways to sense, repair, and signal in response to such challenges. Research studies focused on understanding genome integrity have utilized a variety of model organisms and cutting-edge technologies (e.g., CRISPR/Cas9, NGS-based genome-wide mapping) at the molecular, cellular, organismal, and ecological levels. Mechanistic studies that help define the process of genome integrity maintenance, the impact of such mechanisms on environmental health, and their role in cancer etiology are highly significant and have led to new ways of diagnosing and treating cancers and other human diseases. Because of the many advances in this area of research over the past few years, this Research Topic intends to provide the latest insights on the field of genome integrity and to discuss the trends of current and future studies aimed at improving our understanding of disease pathogenesis and treatment.
This Research Topic is focused on cutting-edge mechanistic studies of genome integrity, environmental health, and cancer etiology, including but not limited to following topics:
1) DNA damage analysis, DNA damage response pathways and DNA repair mechanisms;
2) DNA recombination and transposons, translesion DNA synthesis, DNA replication and DNA replication stress;
3) Epigenetic regulation of genome integrity;
4) New technologies in the field of genome integrity including next-generation-sequencing (NGS)-based genome wide mapping and profiling of DNA damage and repair;
5) Genetic and/or environmental risk factors for cancer etiology;
6) Environmental exposure, DNA integrity and health.
Robert W. Sobol is a scientific consultant for Canal House Biosciences, LLC. All other co-editors declare no conflicts of interest.