Due to oxygen’s crucial role in energy conversion, failure of oxygen delivery may lead to disabilities and the death of aerobic organisms. In addition, oxygen is required for the function of a number of enzymes, such as heme-oxygenase, NO synthase, NADPH oxidase, and formation of reactive oxygen and nitrogen species which all support normal metabolism and immune response. Impaired oxygen delivery occurring upon asphyxia, hemorrhagic shock, stroke or cardiac arrest causes acute or delayed tissue injury and death in severe cases. Tissue injury may also result from secondary circulatory failure induced by the systemic inflammatory response that sets in already after return of circulation. Thus, impaired oxygen delivery and the inflammatory response may create a vicious cycle aggravating acute and delayed clinical manifestation that culminate in multiple organ dysfunction syndrome, a severe life threatening condition with a high mortality, which is still poorly understood. The use of animal models plays a particularly essential role in understanding these complex pathological processes and the development of efficient diagnostic tools and therapeutic approaches.
This Research Topic aims to collect contributions dedicated to shed light on mechanisms and treatments of pathological processes underlying the development of organ dysfunction resulting from hypoxia and ischemia/reperfusion injury with a particular emphasis on the animal models used to uncover pathogenesis, develop diagnostic or therapeutic approaches. Here we aim to present thoroughly described experimental models for the investigation of suitable outcome parameters which also include information on technical difficulties faced and their solution. This implies a very thorough description of the model used, and an honest discussion of the specific limits of both the model and the approach.
We invite reviews presenting new emerging concepts, discussing suitable methods and approaches, and comparing different animal models aiming at understanding the mechanisms of hypoxia induced organ dysfunction. Further contributions may include:
• Experimental studies which investigate the mechanisms underlying local and remote tissue injury, especially when focusing on long term effects.
• Studies discussing results that are counterintuitive, or despite well thought out hypotheses failed to deliver sufficiently convincing data.
• Experimental or methodological studies with a detailed description of the experimental models used or the suitability of the method investigating pathologies accompanied by or resulting in impaired oxygen delivery and other defects in oxygen metabolism.
Due to oxygen’s crucial role in energy conversion, failure of oxygen delivery may lead to disabilities and the death of aerobic organisms. In addition, oxygen is required for the function of a number of enzymes, such as heme-oxygenase, NO synthase, NADPH oxidase, and formation of reactive oxygen and nitrogen species which all support normal metabolism and immune response. Impaired oxygen delivery occurring upon asphyxia, hemorrhagic shock, stroke or cardiac arrest causes acute or delayed tissue injury and death in severe cases. Tissue injury may also result from secondary circulatory failure induced by the systemic inflammatory response that sets in already after return of circulation. Thus, impaired oxygen delivery and the inflammatory response may create a vicious cycle aggravating acute and delayed clinical manifestation that culminate in multiple organ dysfunction syndrome, a severe life threatening condition with a high mortality, which is still poorly understood. The use of animal models plays a particularly essential role in understanding these complex pathological processes and the development of efficient diagnostic tools and therapeutic approaches.
This Research Topic aims to collect contributions dedicated to shed light on mechanisms and treatments of pathological processes underlying the development of organ dysfunction resulting from hypoxia and ischemia/reperfusion injury with a particular emphasis on the animal models used to uncover pathogenesis, develop diagnostic or therapeutic approaches. Here we aim to present thoroughly described experimental models for the investigation of suitable outcome parameters which also include information on technical difficulties faced and their solution. This implies a very thorough description of the model used, and an honest discussion of the specific limits of both the model and the approach.
We invite reviews presenting new emerging concepts, discussing suitable methods and approaches, and comparing different animal models aiming at understanding the mechanisms of hypoxia induced organ dysfunction. Further contributions may include:
• Experimental studies which investigate the mechanisms underlying local and remote tissue injury, especially when focusing on long term effects.
• Studies discussing results that are counterintuitive, or despite well thought out hypotheses failed to deliver sufficiently convincing data.
• Experimental or methodological studies with a detailed description of the experimental models used or the suitability of the method investigating pathologies accompanied by or resulting in impaired oxygen delivery and other defects in oxygen metabolism.
