Regulation of water and sodium excretion in the kidney is critical for maintenance of body fluid homeostasis. Transcellular movement of water and sodium in renal tubular epithelia is mediated by water channel aquaporins and sodium transporters/channels, which are regulated by physiological stimuli, such as hormones. Genetic and acquired alterations of functions of these proteins are accompanied with various acute or chronic kidney diseases. An approach to molecular mechanisms of water and sodium transport in renal tubular epithelia provides insights to development of therapeutic strategies for treatment of fluid and electrolyte disorders in renal failure.
Beyond extensive studies of renal water and sodium transport during several decades, recent multidisciplinary approaches using state-of-the-art techniques have unraveled several enigmas in the regulation of functional proteins during initiation and progression of acute or chronic kidney diseases and contribution to development of renal failure. We aim to update recent advances in multidisciplinary studies to 1) understand molecular underpinnings of water and sodium excretion in the kidney and 2) identify novel physiological/pathophysiological stimuli that are accompanied with fluid and electrolyte disorders.
This Research Topic entitled "Renal Regulation of Water and Sodium in Health and Disease" calls for original articles and reviews regarding the body water and sodium regulation by the kidney in the process of physiology and disease.
In particular, topics of interest include, but are not limited to:
• Mechanism of renal water transport and regulation of aquaporin;
• Mechanism of renal sodium transport and regulation of sodium transporters (channels);
• Roles and regulatory mechanism of renal sodium transporters (channels) in blood pressure;
• Other electrolyte transport, potassium and hydrogen excretion in renal physiology and disease.
Please note that abstract submission is not mandatory. Interested individuals and research groups are welcome to submit their manuscript to this Research Topic without submitting an abstract beforehand.
Regulation of water and sodium excretion in the kidney is critical for maintenance of body fluid homeostasis. Transcellular movement of water and sodium in renal tubular epithelia is mediated by water channel aquaporins and sodium transporters/channels, which are regulated by physiological stimuli, such as hormones. Genetic and acquired alterations of functions of these proteins are accompanied with various acute or chronic kidney diseases. An approach to molecular mechanisms of water and sodium transport in renal tubular epithelia provides insights to development of therapeutic strategies for treatment of fluid and electrolyte disorders in renal failure.
Beyond extensive studies of renal water and sodium transport during several decades, recent multidisciplinary approaches using state-of-the-art techniques have unraveled several enigmas in the regulation of functional proteins during initiation and progression of acute or chronic kidney diseases and contribution to development of renal failure. We aim to update recent advances in multidisciplinary studies to 1) understand molecular underpinnings of water and sodium excretion in the kidney and 2) identify novel physiological/pathophysiological stimuli that are accompanied with fluid and electrolyte disorders.
This Research Topic entitled "Renal Regulation of Water and Sodium in Health and Disease" calls for original articles and reviews regarding the body water and sodium regulation by the kidney in the process of physiology and disease.
In particular, topics of interest include, but are not limited to:
• Mechanism of renal water transport and regulation of aquaporin;
• Mechanism of renal sodium transport and regulation of sodium transporters (channels);
• Roles and regulatory mechanism of renal sodium transporters (channels) in blood pressure;
• Other electrolyte transport, potassium and hydrogen excretion in renal physiology and disease.
Please note that abstract submission is not mandatory. Interested individuals and research groups are welcome to submit their manuscript to this Research Topic without submitting an abstract beforehand.
