Despite a paradigm shift in precision medicine, systemic radiation has remained unchanged for over half a century due to lack of technology with evidence of biological and clinical relevance. Total body irradiation (TBI) is a widely used conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) in hematopoietic malignancies. Treatment related toxicities and relapse are a major limitation of TBI. Overcoming these problems, we designed an image-guided bone marrow targeted radiation delivery system called total marrow irradiation (TMI). There is an emerging shift on the use of TMI based conditioning regimen from conventional TBI strategies in many centers globally. While several studies were reported individually, there is an unmet need for a comprehensive report to shed light on the progress of this multidisciplinary field.
For an in depth understanding of this new multidisciplinary paradigm we will present a review of TBI technology and its clinical benefits and limitations as a conditioning regimen for bone marrow transplant and hematological malignancies. This will provide a rationale for recent advances in high precision targeted and organ sparing radiotherapy to establish a new treatment for hematological malignancies.
In this Research Topic, we aim to cover the recent advances of this new paradigm including technology, physics, biology, imaging, and its clinical benefit, and report on the standardization of TMI across different vendors and centers globally through the consortium. Additionally, the future advancements through a multidisciplinary approach, including molecular imaging, automatization process will also be reported.
The objective is to bring experts from different disciplines and countries together to provide a detailed coverage of this new field. Therefore, scope of this project is transformational, as it will not only cover advances in all aspects of this new field to gain knowledge for scientific progress as well as guide for clinical practice.
This collection aims to focus on three broad categories:
1. Advancement in physics and dosimetry of TMI - We will consider articles focusing on various aspects of this topic and attempt will be made to represent work from different vendors. Additionally, we aim to summarize this area to generate consensus guidelines. Articles on future development will also be encouraged.
2. Application of TMI in clinical practice - As there are large number of centers pursuing various clinical objectives, and as we expect to cover most relevant developments, we expect articles to cover aspects of hematological and radiation oncology. As well, expert opinions or reviews on current clinical practices are encouraged.
3. Imaging and its role for TMI – articles related to the biology of TMI will also be considered.
Despite a paradigm shift in precision medicine, systemic radiation has remained unchanged for over half a century due to lack of technology with evidence of biological and clinical relevance. Total body irradiation (TBI) is a widely used conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) in hematopoietic malignancies. Treatment related toxicities and relapse are a major limitation of TBI. Overcoming these problems, we designed an image-guided bone marrow targeted radiation delivery system called total marrow irradiation (TMI). There is an emerging shift on the use of TMI based conditioning regimen from conventional TBI strategies in many centers globally. While several studies were reported individually, there is an unmet need for a comprehensive report to shed light on the progress of this multidisciplinary field.
For an in depth understanding of this new multidisciplinary paradigm we will present a review of TBI technology and its clinical benefits and limitations as a conditioning regimen for bone marrow transplant and hematological malignancies. This will provide a rationale for recent advances in high precision targeted and organ sparing radiotherapy to establish a new treatment for hematological malignancies.
In this Research Topic, we aim to cover the recent advances of this new paradigm including technology, physics, biology, imaging, and its clinical benefit, and report on the standardization of TMI across different vendors and centers globally through the consortium. Additionally, the future advancements through a multidisciplinary approach, including molecular imaging, automatization process will also be reported.
The objective is to bring experts from different disciplines and countries together to provide a detailed coverage of this new field. Therefore, scope of this project is transformational, as it will not only cover advances in all aspects of this new field to gain knowledge for scientific progress as well as guide for clinical practice.
This collection aims to focus on three broad categories:
1. Advancement in physics and dosimetry of TMI - We will consider articles focusing on various aspects of this topic and attempt will be made to represent work from different vendors. Additionally, we aim to summarize this area to generate consensus guidelines. Articles on future development will also be encouraged.
2. Application of TMI in clinical practice - As there are large number of centers pursuing various clinical objectives, and as we expect to cover most relevant developments, we expect articles to cover aspects of hematological and radiation oncology. As well, expert opinions or reviews on current clinical practices are encouraged.
3. Imaging and its role for TMI – articles related to the biology of TMI will also be considered.