Chronic kidney disease (CKD) is a clinical condition that describes the permanent loss of kidney function. CKD is estimated to affect around 10% of the world population and be attributable to more than one million deaths each year. The progression of CKD is characterized by an array of metabolic disturbances and clinical manifestations in uremia. CKD occasionally progresses to kidney failure (i.e. chronic end stage organ failure), whereby, kidney replacement therapy (KRT) is required to remove excess body water, filter uremic retention solutes, deliver base, and ultimately sustain life.
Peritoneal Dialysis is a KRT that emerged in the 1960's as an alternative modality to treat people with kidney failure. This therapy evolved over the past 5 decades and proved to be a viable treatment option improving the life of millions of people since its introduction to clinical practice. It provides a similar metabolic control and patient survival in comparison to hemodialysis. Peritoneal Dialysis is a patient centric KRT that can be performed at home and has favorable attributes of continuous filtration via actively washing the peritoneal cavity with dialysate fluid.
However, from the understanding of the peritoneal membrane disorders observed after commencement of Peritoneal Dialysis to the clinical impact on metabolic parameters, quality of life, and patient survival in clinical practice, there are remarkable gaps of knowledge in the basic and clinical fields.
Peritoneal Dialysis is a life sustaining kidney replacement therapy (KRT) and the most common dialysis modality that can be performed by people with kidney failure at home. Peritoneal Dialysis is used to treat more than 5% and upward to 80% of the overall kidney failure population in different countries. Despite the importance of Peritoneal Dialysis, the basic and clinical evidence describing the physiology and outcomes associated with the modalities is underrepresented in the literature. The goal of this special Research Topic is to organize a globally representative collection of original research articles demonstrating the latest basic and clinical evidence on Peritoneal Dialysis, as well as key review articles detailing the state of the art.
The Research Topic has the scope of creating a collection of articles detailing the latest basic and clinical evidence describing the physiology and outcomes in Peritoneal Dialysis.
The specific themes we are inviting researchers to contribute to this Research Topic include:
-Peritoneal Membrane Biology and Physiology
-Metabolic Disturbances in Peritoneal Dialysis
-COVID-19 and Peritoneal Dialysis
-Peritoneal Dialysis related infections
-Physiological modeling and artificial intelligence in Peritoneal Dialysis
-Physiology and clinical outcomes in Peritoneal Dialysis
Please note that abstract submission is not mandatory. Interested individuals and research groups are welcome to submit their manuscript to this Research Topic without submitting an abstract beforehand.
Topic Editor Dr. Thyago Moraes is a speaker from AstraZeneca, Baxter Healthcare, Boehringer-Lilly and Takeda. He also is a consultant for AstraZeneca and Baxter Healthcare. Topic Editor Dr. John Larkin is an employee of Fresenius Medical Care. Topic Editor Dr. Pasqual Barretti declares no competing interests with regards to the Research Topic subject.
Chronic kidney disease (CKD) is a clinical condition that describes the permanent loss of kidney function. CKD is estimated to affect around 10% of the world population and be attributable to more than one million deaths each year. The progression of CKD is characterized by an array of metabolic disturbances and clinical manifestations in uremia. CKD occasionally progresses to kidney failure (i.e. chronic end stage organ failure), whereby, kidney replacement therapy (KRT) is required to remove excess body water, filter uremic retention solutes, deliver base, and ultimately sustain life.
Peritoneal Dialysis is a KRT that emerged in the 1960's as an alternative modality to treat people with kidney failure. This therapy evolved over the past 5 decades and proved to be a viable treatment option improving the life of millions of people since its introduction to clinical practice. It provides a similar metabolic control and patient survival in comparison to hemodialysis. Peritoneal Dialysis is a patient centric KRT that can be performed at home and has favorable attributes of continuous filtration via actively washing the peritoneal cavity with dialysate fluid.
However, from the understanding of the peritoneal membrane disorders observed after commencement of Peritoneal Dialysis to the clinical impact on metabolic parameters, quality of life, and patient survival in clinical practice, there are remarkable gaps of knowledge in the basic and clinical fields.
Peritoneal Dialysis is a life sustaining kidney replacement therapy (KRT) and the most common dialysis modality that can be performed by people with kidney failure at home. Peritoneal Dialysis is used to treat more than 5% and upward to 80% of the overall kidney failure population in different countries. Despite the importance of Peritoneal Dialysis, the basic and clinical evidence describing the physiology and outcomes associated with the modalities is underrepresented in the literature. The goal of this special Research Topic is to organize a globally representative collection of original research articles demonstrating the latest basic and clinical evidence on Peritoneal Dialysis, as well as key review articles detailing the state of the art.
The Research Topic has the scope of creating a collection of articles detailing the latest basic and clinical evidence describing the physiology and outcomes in Peritoneal Dialysis.
The specific themes we are inviting researchers to contribute to this Research Topic include:
-Peritoneal Membrane Biology and Physiology
-Metabolic Disturbances in Peritoneal Dialysis
-COVID-19 and Peritoneal Dialysis
-Peritoneal Dialysis related infections
-Physiological modeling and artificial intelligence in Peritoneal Dialysis
-Physiology and clinical outcomes in Peritoneal Dialysis
Please note that abstract submission is not mandatory. Interested individuals and research groups are welcome to submit their manuscript to this Research Topic without submitting an abstract beforehand.
Topic Editor Dr. Thyago Moraes is a speaker from AstraZeneca, Baxter Healthcare, Boehringer-Lilly and Takeda. He also is a consultant for AstraZeneca and Baxter Healthcare. Topic Editor Dr. John Larkin is an employee of Fresenius Medical Care. Topic Editor Dr. Pasqual Barretti declares no competing interests with regards to the Research Topic subject.
