About this Research Topic
Hypoxia is a condition which induces significant changes in cardiovascular control mechanisms. Its relevance in cardiovascular disease is many-fold: hypoxia may be the result of cardiovascular pathological conditions (eg. heart failure, pulmonary thromboembolism), hypoxia due to environmental factors (in particular high altitude) may affect body functions of individuals with preexisting cardiovascular disease, hypoxia may directly cause cardiovascular complications (eg. acute and chronic mountain sickness), hypoxia may modify the effect of cardiovascular therapies and controlled hypoxia may represent a treatment modality (eg. interval hypoxic training). Despite the high prevalence and frequent coexistence of hypoxia and cardiovascular disease, there are still large areas of uncertainty in this regard.
This Research Topic aims at summarizing the available information and providing more insight into pathophysiological mechanisms linking hypoxia to cardiovascular disease, clinical and epidemiological implications of this relationship and therapeutic options. This topic is particularly relevant given the prevalence of cardiovascular diseases characterized by hypoxia (heart failure with reduced ejection fraction, ischemic heart disease and, as new evidence suggests, cardiomyopathies such as hypertrophic cardiomyopathy and recently defined pathological entities such as heart failure with preserved ejection fraction).
Original articles, as well as reviews of previously published literature, will be considered focusing mainly on the following topics:
1) Molecular and physiological mechanisms involved in the relationship between hypoxia and cardiovascular disease.
2) Clinical relevance of hypoxia for cardiovascular disease.
3) Epidemiological impact of hypoxia on cardiovascular disease.
4) Efficacy and safety of cardiovascular treatments (both pharmacological and non-pharmacological) in patients exposed to hypoxia.
5) Hypoxia as a tool for prevention and treatment of cardiovascular disease.
This Research Topic aims at summarizing the available information and providing more insight into pathophysiological mechanisms linking hypoxia to cardiovascular disease, clinical and epidemiological implications of this relationship and therapeutic options. This topic is particularly relevant given the prevalence of cardiovascular diseases characterized by hypoxia (heart failure with reduced ejection fraction, ischemic heart disease and, as new evidence suggests, cardiomyopathies such as hypertrophic cardiomyopathy and recently defined pathological entities such as heart failure with preserved ejection fraction).
Original articles, as well as reviews of previously published literature, will be considered focusing mainly on the following topics:
1) Molecular and physiological mechanisms involved in the relationship between hypoxia and cardiovascular disease.
2) Clinical relevance of hypoxia for cardiovascular disease.
3) Epidemiological impact of hypoxia on cardiovascular disease.
4) Efficacy and safety of cardiovascular treatments (both pharmacological and non-pharmacological) in patients exposed to hypoxia.
5) Hypoxia as a tool for prevention and treatment of cardiovascular disease.
Keywords: hypoxia, high altitude, cardiovascular disease, cardiovascular risk factors, hypertension, CVD
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