GI cancers remain the most frequent cancer types and the leading cause of cancer deaths worldwide. According to GLOBOCAN 2020 data, colorectal ranks third in terms of incidence, but second in terms of mortality. Gastric cancer ranks fifth for incidence and fourth for mortality globally. Epigenetic dysregulation is recognized as a fundamental mechanism in cancer. Alterations in epigenetic regulators includes disorders in DNA methylation, histone posttranslational modifications, chromatin remodeling complex.
In another respect, alterations in non-coding RNAs such as miRNA, lncRNA, circRNA, among others, are also key components of epigenetic regulatory mechanisms which account for cancer development and progression. How these epigenetic regulatory mechanisms get involved in GI cancer tumorigenesis remains unclear and needs to be further elucidated.
This Research Topic focuses on the epigenetic dysregulation in GI cancer. We call for papers which will lead to insights and further mechanistic understanding into all above epigenetic issues, as well as providing novel therapeutic strategies.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
GI cancers remain the most frequent cancer types and the leading cause of cancer deaths worldwide. According to GLOBOCAN 2020 data, colorectal ranks third in terms of incidence, but second in terms of mortality. Gastric cancer ranks fifth for incidence and fourth for mortality globally. Epigenetic dysregulation is recognized as a fundamental mechanism in cancer. Alterations in epigenetic regulators includes disorders in DNA methylation, histone posttranslational modifications, chromatin remodeling complex.
In another respect, alterations in non-coding RNAs such as miRNA, lncRNA, circRNA, among others, are also key components of epigenetic regulatory mechanisms which account for cancer development and progression. How these epigenetic regulatory mechanisms get involved in GI cancer tumorigenesis remains unclear and needs to be further elucidated.
This Research Topic focuses on the epigenetic dysregulation in GI cancer. We call for papers which will lead to insights and further mechanistic understanding into all above epigenetic issues, as well as providing novel therapeutic strategies.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
