There is a growing socio-economic need (i.e. “aging society”) for effective and reproducible strategies to repair musculoskeletal tissue in general. In particular, acute tendon injury and chronic tendinopathies remain clinically challenging and novel treatment modalities are urgently needed. A low number of metabolically inactive cells combined with the avascular nature of tendons delays healing, whilst the innate reparative processes are incomplete and often associated with the formation of scar tissue compromising mechanical function. Therefore, novel treatments need to break the limits of tendon regeneration by harnessing novel cell instructive biomaterials and immunomodulatory, pro-regenerative therapeutic agents.
Despite significant advancements in tissue engineering (e.g. sophisticated combination of scaffolds, cell biologics), the clinical impact for the regeneration of tendons remains limited. For the development of functional reparative tendon therapies, we need to pin down the molecular and cellular mechanisms amenable to modulate endogenous (or exogenous) cell behavior towards functional tendon repair and regeneration.
This Research Topic will compile critical reviews and original research articles covering novel scientific discoveries in the area of e.g. tendon physiology, mechanobiology, adaptive and innate immune responses, tissue engineering strategies, and how these insights instruct new treatments for tendinopathies.
We encourage the submission of original research and reviews related, but not limited, to:
- Adaptive and innate immunity in tendinopathy
- Role of the extracellular matrix in tendon development and tissue homeostasis
- Tendon biomechanics
- In vitro and ex vivo models in tendon research
- Biomaterials for tendon repair
- ATMPs and biologics for treating tendinopathies
- Impact of aging/ co-morbidities on tendinopathy development
There is a growing socio-economic need (i.e. “aging society”) for effective and reproducible strategies to repair musculoskeletal tissue in general. In particular, acute tendon injury and chronic tendinopathies remain clinically challenging and novel treatment modalities are urgently needed. A low number of metabolically inactive cells combined with the avascular nature of tendons delays healing, whilst the innate reparative processes are incomplete and often associated with the formation of scar tissue compromising mechanical function. Therefore, novel treatments need to break the limits of tendon regeneration by harnessing novel cell instructive biomaterials and immunomodulatory, pro-regenerative therapeutic agents.
Despite significant advancements in tissue engineering (e.g. sophisticated combination of scaffolds, cell biologics), the clinical impact for the regeneration of tendons remains limited. For the development of functional reparative tendon therapies, we need to pin down the molecular and cellular mechanisms amenable to modulate endogenous (or exogenous) cell behavior towards functional tendon repair and regeneration.
This Research Topic will compile critical reviews and original research articles covering novel scientific discoveries in the area of e.g. tendon physiology, mechanobiology, adaptive and innate immune responses, tissue engineering strategies, and how these insights instruct new treatments for tendinopathies.
We encourage the submission of original research and reviews related, but not limited, to:
- Adaptive and innate immunity in tendinopathy
- Role of the extracellular matrix in tendon development and tissue homeostasis
- Tendon biomechanics
- In vitro and ex vivo models in tendon research
- Biomaterials for tendon repair
- ATMPs and biologics for treating tendinopathies
- Impact of aging/ co-morbidities on tendinopathy development
