Epilepsy is a chronic neurological disease and patients with epilepsy have an increased risk for cognitive, behavioral, and psychosocial disorders that can adversely impact the quality of life. To date, there are over 25 anti-epileptic drugs in the use, and still 30% of the population is refractory to one or another drug. Both experimental and clinical studies are equally important to not only understand the drug targets and disease mechanisms, but also discovering more potent, safe and efficacious drugs.
The aim of this Research Topic is to highlight translational epilepsy which involves basic, clinical and translational research implying epilepsy and other seizure disorders.
Translational research is an important aspect of epilepsy research, and is expected to play a key role in improving patients' quality of life. It is also expected to help in understanding the complexity of the disease condition and of its comorbidities. Discovery of novel potential anti-epileptics and their mechanism will also be included in this Research Topic.
In this Research Topic, Editors will welcome submissions from basic, clinical and translational studies and review papers that summarize current knowledge and point out gaps in our understanding of epilepsy and associated disorders, disease mechanisms, comorbidities, and related research for novel drug discovery.
This includes, but is not limited to:
1. Novel epilepsy mechanisms including role of neuroinflammatory and neurodegenerative markers
2. Role of animal models in translational epilepsy research
3. Drug repurposing and drug discovery for acquired and genetic epilepsies
4. Inflammatory biomarkers in epilepsy associated comorbidities
Epilepsy is a chronic neurological disease and patients with epilepsy have an increased risk for cognitive, behavioral, and psychosocial disorders that can adversely impact the quality of life. To date, there are over 25 anti-epileptic drugs in the use, and still 30% of the population is refractory to one or another drug. Both experimental and clinical studies are equally important to not only understand the drug targets and disease mechanisms, but also discovering more potent, safe and efficacious drugs.
The aim of this Research Topic is to highlight translational epilepsy which involves basic, clinical and translational research implying epilepsy and other seizure disorders.
Translational research is an important aspect of epilepsy research, and is expected to play a key role in improving patients' quality of life. It is also expected to help in understanding the complexity of the disease condition and of its comorbidities. Discovery of novel potential anti-epileptics and their mechanism will also be included in this Research Topic.
In this Research Topic, Editors will welcome submissions from basic, clinical and translational studies and review papers that summarize current knowledge and point out gaps in our understanding of epilepsy and associated disorders, disease mechanisms, comorbidities, and related research for novel drug discovery.
This includes, but is not limited to:
1. Novel epilepsy mechanisms including role of neuroinflammatory and neurodegenerative markers
2. Role of animal models in translational epilepsy research
3. Drug repurposing and drug discovery for acquired and genetic epilepsies
4. Inflammatory biomarkers in epilepsy associated comorbidities
