The integumentary system is susceptible to many diseases and disorders, ranging from allergy manifestations, to permanent diseases, i. e. rosacea, vitiligo and psoriasis, to tumors, like melanoma, and to the physiological process of ageing. The skin is also largely involved in the immune response and its health can be affected by autoimmune disorders, i.e. lupus, and by infection by many microorganisms: fungi, bacteria and viruses as well. In addition, the skin is responsible for defending the organisms from UV radiation and many are the disorders related to melanin synthesis. However, the cellular mechanisms that regulate the occurrence of most of these conditions are still not fully understood, and there are no effective therapies for most of these skin disorders.
Medicinal plants and their derivatives can represent an innovative strategy for treating various human diseases, including disorders related to the integumentary system. Since medicinal plants and their extracts are often used in clinical practice in the basis of tradition and ethnobotanical experience, a rational characterization of their use needs to be provided and evidence of their long term safety and activity needs to be collected.
The purpose of this Research Topic is to explore the potential therapeutic role of many natural compounds and medicinal plant extracts in the management of pathological conditions of the integumentary system and discuss the role of natural compounds and extracts in the development of skin disorders.
Phytochemical characterization and pharma-toxicological evaluation of plant extracts and natural compounds are recommended as an essential requirement for an accurate evaluation of the mechanisms of action. The investigation of the relationship between quali-quantitative secondary metabolite fingerprint and the modulation of biochemical pathways are encouraged as well.
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All the manuscripts submitted to this project will be peer-reviewed and need to fully comply with the
Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version
here).
The integumentary system is susceptible to many diseases and disorders, ranging from allergy manifestations, to permanent diseases, i. e. rosacea, vitiligo and psoriasis, to tumors, like melanoma, and to the physiological process of ageing. The skin is also largely involved in the immune response and its health can be affected by autoimmune disorders, i.e. lupus, and by infection by many microorganisms: fungi, bacteria and viruses as well. In addition, the skin is responsible for defending the organisms from UV radiation and many are the disorders related to melanin synthesis. However, the cellular mechanisms that regulate the occurrence of most of these conditions are still not fully understood, and there are no effective therapies for most of these skin disorders.
Medicinal plants and their derivatives can represent an innovative strategy for treating various human diseases, including disorders related to the integumentary system. Since medicinal plants and their extracts are often used in clinical practice in the basis of tradition and ethnobotanical experience, a rational characterization of their use needs to be provided and evidence of their long term safety and activity needs to be collected.
The purpose of this Research Topic is to explore the potential therapeutic role of many natural compounds and medicinal plant extracts in the management of pathological conditions of the integumentary system and discuss the role of natural compounds and extracts in the development of skin disorders.
Phytochemical characterization and pharma-toxicological evaluation of plant extracts and natural compounds are recommended as an essential requirement for an accurate evaluation of the mechanisms of action. The investigation of the relationship between quali-quantitative secondary metabolite fingerprint and the modulation of biochemical pathways are encouraged as well.
---
All the manuscripts submitted to this project will be peer-reviewed and need to fully comply with the
Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version
here).
