The NF-?B family of dimeric transcription factors mediates critical biological functions in inflammation, innate immunity, cell proliferation and survival. In contrast, deregulation of NF-?B pathway components has been causally linked to the development of pathological processes including cancers, inflammatory and metabolic disorders. The complex roles of NF-?B in a multitude of cellular processes and diseases could be attributed to the hundreds of target genes whose expression are regulated by NF-?B factors involving transcriptional or epigenetic mechanisms. While previous investigations were mostly focused on the regulation of classical NF-?B pathway, there is increasing evidence for noncanonical NF-?B functions in inflammation and cancer. The microbiome also plays significant roles in regulating NF-?B signaling and abnormal perturbations in gut microbiota are associated with the incidence of diseases such as inflammatory bowel disease, Parkinson’s disease, type 2 diabetes mellitus and cancer, adding a new dimension to the biology of modern diseases. Although the aetiologies of these complex diseases are multifactorial, the involvement of several inflammatory loops are quite evident. NF-?B, being a key regulator in the crosstalk between multiple inflammatory pathways, serves as a matchmaker between inflammation and these modern diseases.
This Research Topic seeks to cover outstanding research illustrating recent developments in the regulatory roles of NF-?B factors in inflammation and cancer, as well as novel investigations which explore the tripartite link between microbiota, NF-?B and modern diseases.
Specific areas to be covered in this Research Topic may include the following:
1. NF-?B mediated transcriptional or epigenetic mechanisms in inflammation and cancer
2. Transcriptional specificity of NF-?B factors in inflammation and cancer
3. Role of NF-?B signaling in tumor-promoting inflammation
4. Regulation of NF-?B signaling by gut microbiota in health and disease
5. NF-?B signaling in stem cells and development, particularly cancer stem cells
6. Role of NF-?B associated long non-coding RNAs (lncRNAs) in inflammation and cancer progression
7. Role of noncanonical NF-?B signaling in inflammation and cancer
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