Hemodynamic factors extending beyond conventional blood pressure, including flow pulsatility, pressure transmission, and impedance mismatching, are of consequence to end-organs such as the brain and may accelerate brain aging. Abnormal hemodynamic profiles can lead to pathology, including cerebral small vessel disease and brain atrophy. For example, aortic stiffening and the result and increased pressure transmission to the brain can lead to hypoperfusion and damage to the cerebral microvasculature, which are associated with cognitive impairment and dementia.
This Research Topic is interested in articles examining vascular-hemodynamic factors and brain aging, including epidemiological, clinical, physiological and measurement-based studies, and on studies of sex and race/ethnic differences. The Topic Editors welcome various types of articles, such as original research, methodology articles, and review articles.
Potential paper themes include:
1) Mechanistic pathways.
2) Systems physiology.
3) Interventions.
4) Epidemiology.
5) Population characteristics, including sex and race/ethnic differences.
6) Measurement considerations.
Hemodynamic factors extending beyond conventional blood pressure, including flow pulsatility, pressure transmission, and impedance mismatching, are of consequence to end-organs such as the brain and may accelerate brain aging. Abnormal hemodynamic profiles can lead to pathology, including cerebral small vessel disease and brain atrophy. For example, aortic stiffening and the result and increased pressure transmission to the brain can lead to hypoperfusion and damage to the cerebral microvasculature, which are associated with cognitive impairment and dementia.
This Research Topic is interested in articles examining vascular-hemodynamic factors and brain aging, including epidemiological, clinical, physiological and measurement-based studies, and on studies of sex and race/ethnic differences. The Topic Editors welcome various types of articles, such as original research, methodology articles, and review articles.
Potential paper themes include:
1) Mechanistic pathways.
2) Systems physiology.
3) Interventions.
4) Epidemiology.
5) Population characteristics, including sex and race/ethnic differences.
6) Measurement considerations.
