Cardiovascular disease causes substantial economic and social burden worldwide. Intensive studies have demonstrated that dysregulation of metabolism is a common feature in various cardiovascular diseases. For instance, excessive accumulation of lipids in the heart causes lipotoxic cardiomyopathy and heart failure. Mitochondria are powerhouses for oxidative and energetic metabolism and their function is regulated at multiple levels. Decreased function of the failing heart is associated with mitochondrial abnormalities including abnormal mitochondrial dynamics of fission and fusion, oxidation of metabolic substrates shifted from fatty acid substrates to glucose, accumulation of reactive oxygen species, and decreased production of energy. Dysregulation of metabolism is not only observed in adult-onset cardiovascular disease, but also happens in congenital heart disease. In addition, dysregulation of metabolic substrates may contribute to multi-organ disorders. Restoring normal metabolic processes represents a promising therapeutic strategy for cardiovascular disease.
This Research Topic focuses on recent advances and challenges in dissecting the metabolic mechanisms regulating disease pathogenesis and progression.
The Research Topic covers the following topics, but not limited to:
1) Metabolites serve as biomarkers for diagnosis of cardiovascular disease.
2) Molecular gaps between metabolic and epigenetic regulations during disease pathogenesis.
3) Approaches profiling metabolomics and metabolites.
4) Metabolic dysregulation in the control of cardiomyopathy, cardiac fibrosis, and heart failure.
5) Therapeutics targeting metabolic processes.
6) Mitochondrial homeostasis in cardiomyopathy and heart failure.
7) Metabolic crosstalk between cardiovascular disease and others.
Cardiovascular disease causes substantial economic and social burden worldwide. Intensive studies have demonstrated that dysregulation of metabolism is a common feature in various cardiovascular diseases. For instance, excessive accumulation of lipids in the heart causes lipotoxic cardiomyopathy and heart failure. Mitochondria are powerhouses for oxidative and energetic metabolism and their function is regulated at multiple levels. Decreased function of the failing heart is associated with mitochondrial abnormalities including abnormal mitochondrial dynamics of fission and fusion, oxidation of metabolic substrates shifted from fatty acid substrates to glucose, accumulation of reactive oxygen species, and decreased production of energy. Dysregulation of metabolism is not only observed in adult-onset cardiovascular disease, but also happens in congenital heart disease. In addition, dysregulation of metabolic substrates may contribute to multi-organ disorders. Restoring normal metabolic processes represents a promising therapeutic strategy for cardiovascular disease.
This Research Topic focuses on recent advances and challenges in dissecting the metabolic mechanisms regulating disease pathogenesis and progression.
The Research Topic covers the following topics, but not limited to:
1) Metabolites serve as biomarkers for diagnosis of cardiovascular disease.
2) Molecular gaps between metabolic and epigenetic regulations during disease pathogenesis.
3) Approaches profiling metabolomics and metabolites.
4) Metabolic dysregulation in the control of cardiomyopathy, cardiac fibrosis, and heart failure.
5) Therapeutics targeting metabolic processes.
6) Mitochondrial homeostasis in cardiomyopathy and heart failure.
7) Metabolic crosstalk between cardiovascular disease and others.