Cerebrovascular diseases (CVDs), including stroke, transient ischemic attack (TIA), aneurysm and vascular malformation, lead to the disruption of the blood flow and alternation of the anatomical structure in the brain. CVDs are the most common life-threatening neurological disease worldwide. The management of CVDs aims to prevent and cure these diseases to reduce the enormous social and economic burden. Recent studies have shown that genetic variation, including somatic and germline gene mutation and fluctuation of gene expression, plays important roles in the pathogenesis of CVDs. Thus, using the precision medicine approach in the management of CVDs is becoming increasingly important for lowering morbidity and improving neurological outcomes in patients. The initiative of precision medicine of CVDs was aiming to promote CVD treatments to a more microscopic and individualized level through laboratory and clinical research. In recent years, the concept of precision medicine has been extended from microcosmic works, such as customized molecular diagnostic tools and targeted drugs, to macroscopic works, such as individualized neuroimaging assessment, precision hybrid operation techniques. Further studies of the morphology, functional topology, hemodynamics, angio-architectural, and precision surgical techniques in CVDs will greatly contribute to the development of precision medicine of CVDs, which will greatly contribute to saving patients from neurological impacts after CVDs.
This Research Topic focuses on the precision medical management of CVDs, especially in the vascular surgery and endovascular therapy fields. The collection is expected to include recent essential advances on the early precision diagnosis, preoperative and prognostic functional evaluation that could contribute to the precision medical management of CVDs. Clinical investigations based on practical issues and fundamental research with excellent translational prospects are welcome. Investigation of the precision medical management of CVDs is expected in (1) development of microcosmic laboratory and translational works for early screening and early (pre-)hospital diagnosis of CVD; (2) development of meso- and macroscopic works on neuroimaging and models for preoperative and prognostic assessment; and (3) development and promotion of personalized surgical techniques and strategies, and clarification of therapeutic indications.
This Research Topic will include, but are not limited to, the following themes:
• Studies use genomic sequencing, single-cell sequencing, and big data analytics to identify biomarkers and pathways that relevant to the occurrence and development of CVDs and provide potential contributions to the precision medical management of CVDs.
• Developing models or tools for the assessment of risks and prognosis of surgical treatment in a precision medicine approach.
• Providing the threshold of surgery or directing the therapeutic strategy from the aspects of functional imaging, radiomics, hemodynamics, angioarchitecture, particularly with the assistance of big data
• Reviewing technical considerations regarding current available personalized surgical treatments and innovative treatment modalities, such as microsurgery, endovascular surgery, radiosurgery, and one-staged or staged multimodality treatment
• Reviewing policy, regulations, and guidelines related to CVD management based on comprehensive literature review generating by academia, relevant societies, regulatory bodies, or industries
Cerebrovascular diseases (CVDs), including stroke, transient ischemic attack (TIA), aneurysm and vascular malformation, lead to the disruption of the blood flow and alternation of the anatomical structure in the brain. CVDs are the most common life-threatening neurological disease worldwide. The management of CVDs aims to prevent and cure these diseases to reduce the enormous social and economic burden. Recent studies have shown that genetic variation, including somatic and germline gene mutation and fluctuation of gene expression, plays important roles in the pathogenesis of CVDs. Thus, using the precision medicine approach in the management of CVDs is becoming increasingly important for lowering morbidity and improving neurological outcomes in patients. The initiative of precision medicine of CVDs was aiming to promote CVD treatments to a more microscopic and individualized level through laboratory and clinical research. In recent years, the concept of precision medicine has been extended from microcosmic works, such as customized molecular diagnostic tools and targeted drugs, to macroscopic works, such as individualized neuroimaging assessment, precision hybrid operation techniques. Further studies of the morphology, functional topology, hemodynamics, angio-architectural, and precision surgical techniques in CVDs will greatly contribute to the development of precision medicine of CVDs, which will greatly contribute to saving patients from neurological impacts after CVDs.
This Research Topic focuses on the precision medical management of CVDs, especially in the vascular surgery and endovascular therapy fields. The collection is expected to include recent essential advances on the early precision diagnosis, preoperative and prognostic functional evaluation that could contribute to the precision medical management of CVDs. Clinical investigations based on practical issues and fundamental research with excellent translational prospects are welcome. Investigation of the precision medical management of CVDs is expected in (1) development of microcosmic laboratory and translational works for early screening and early (pre-)hospital diagnosis of CVD; (2) development of meso- and macroscopic works on neuroimaging and models for preoperative and prognostic assessment; and (3) development and promotion of personalized surgical techniques and strategies, and clarification of therapeutic indications.
This Research Topic will include, but are not limited to, the following themes:
• Studies use genomic sequencing, single-cell sequencing, and big data analytics to identify biomarkers and pathways that relevant to the occurrence and development of CVDs and provide potential contributions to the precision medical management of CVDs.
• Developing models or tools for the assessment of risks and prognosis of surgical treatment in a precision medicine approach.
• Providing the threshold of surgery or directing the therapeutic strategy from the aspects of functional imaging, radiomics, hemodynamics, angioarchitecture, particularly with the assistance of big data
• Reviewing technical considerations regarding current available personalized surgical treatments and innovative treatment modalities, such as microsurgery, endovascular surgery, radiosurgery, and one-staged or staged multimodality treatment
• Reviewing policy, regulations, and guidelines related to CVD management based on comprehensive literature review generating by academia, relevant societies, regulatory bodies, or industries
