About this Research Topic

Background

The prevalence of diabetes mellitus is increasing rapidly around the world. This disease is accompanied by a large variety of multiple organ injuries. For example, diabetic kidney disease (DKD) is affecting one in three patients with diabetes, and cardiovascular (CV) disease is the first cause of death for these patients.

The pathophysiology is complex and heterogenic, and the therapeutic strategies are limited.

The goal of this Research Topic is to collect the recent advances on a timely diagnosis and prompt treatment with the final aim to retard the progression of diabetes-related organ injury. To achieve this, a better understanding of its complex pathophysiology is needed. Early identification of high-risk patients and personalized therapies have the potential to relieve organ injury due to diabetes.

A system biology approach integrating large-scale omic data is well suited to unravel the molecular mechanisms driving diabetes-related organ injury and may offer new therapeutic opportunities. Identification of epigenetic signatures, including non-coding RNAs (ncRNAs) of diabetes-related organ injury, might also give hints on medical therapeutic approaches.

This Research Topic focuses on the research progress on diagnostic biomarkers and therapeutic targets in diabetes-related organ injury. We encourage both original research and review articles.

Potential topics include, but are not limited to, the following:

• Epigenetics events that could act as diagnostic biomarkers.
• non-coding RNAs as diagnostic biomarkers and therapeutic targets in the clinical treatment
• System biology approaches with the aim to unravel the molecular mechanism behind diabetes-related organ injuries
• Large scale omics approaches
• Molecular mechanisms which are at the basis of variability in drug response

Keywords: therapeutic targets, diabetes-related organ injury, non coding RNAs, gene polimorphism, epigenetic

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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