About this Research Topic
Volume 1 of RNA regulation in development and disease grouped 19 review and original research articles that highlighted the complexity and diversity of mechanisms that govern the life and functions of protein-coding RNAs in the context of organismal development and disease pathogenesis. In Volume 2, we will continue to explore this topic with a particular emphasis on the role of non-coding RNAs in the formation and activity of nuclear and cytoplasmic ribonucleoprotein (RNP) complexes/condensates.
Accumulating evidence indicates that the subcellular localization and activity of RNA-binding proteins (RBPs) is controlled by a complex network of non-coding RNAs that include but are not limited to micro RNAs and long non-coding RNAs. Such regulatory RNAs are an integral component of the RBP interactome and appear to function as chaperones and regulators to modulate mRNA metabolism and ultimately reprogram the cell proteome.
The combination of Omics and live-cell imaging approaches has revealed the existence of these complex regulatory networks but our understanding of their composition, dynamics, and function is only at a nascent stage.
Hence, in Volume 2 we welcome Original Research papers, Reviews, Mini-reviews, Opinions, Hypotheses, Theory articles, and Methods papers, that discuss the current state of knowledge and shed light on this exciting and novel research field.
Accumulating evidence indicates that the subcellular localization and activity of RNA-binding proteins (RBPs) is controlled by a complex network of non-coding RNAs that include but are not limited to micro RNAs and long non-coding RNAs. Such regulatory RNAs are an integral component of the RBP interactome and appear to function as chaperones and regulators to modulate mRNA metabolism and ultimately reprogram the cell proteome.
The combination of Omics and live-cell imaging approaches has revealed the existence of these complex regulatory networks but our understanding of their composition, dynamics, and function is only at a nascent stage.
Hence, in Volume 2 we welcome Original Research papers, Reviews, Mini-reviews, Opinions, Hypotheses, Theory articles, and Methods papers, that discuss the current state of knowledge and shed light on this exciting and novel research field.
Keywords: Ribonucleoprotein (RNP), non-coding RNA, RNA-binding protein (RBP), RNA metabolism, development, disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
