Hearing Loss: Mechanisms and Prevention

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views

35

articles

Editorial

03 February 2022

Editorial: Hearing Loss: Mechanisms and Prevention

Renjie Chai

,

Hongzhe Li

,

Tao Yang

,

Shan Sun

and

Yongyi Yuan

3,873 views

5 citations

Editors

5

Southeast University

VA Loma Linda Healthcare System, Veterans Health Administration, United States Department of Veterans Affairs

Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University

Eye and Ent Hospital, Fudan University

Department of Otolaryngology Head and Neck Surgery, PLA General Hospital

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Hearing loss is the most common sensory disorder that affects about 466 million people of all ages all over the world. Sensorineural hearing loss (SNHL) is the most common type of hearing loss. Various stress and injury could lead to the SNHL, including genetic factors, acoustic trauma, noise exposure, ototoxic drugs, inflammation or ageing. The irreversible loss of sensory hair cells and the following degeneration of spiral ganglion neurons are the main cause of SNHL. SNHL is not yet curable in the clinic because of the irreversible death of hair cells and the degeneration of spiral ganglion neurons in the cochlea.

Recent years, exciting animal studies on signalling pathway manipulation, gene therapy, and stem cell transplantation as well as pharmaceutical agents demonstrated that hair cells and spiral ganglion neurons could be regenerated and indicated that hearing loss might eventually be curable in the future. This Research Topic will focus on recent advances in the mechanism and prevention of hearing loss.

In this Research Topic, we invite authors to submit high-quality original research articles and reviews. Researchers and clinicians are encouraged to submit their work including basic research, clinical research and translational research. Potential topics include, but are not limited to:

• Gene therapy of hearing loss
• Hair cell and spiral ganglion neuron regeneration
• Spiral ganglion neuron refinement and retraction
• Application of bio-materials in improving the plasticity of spiral ganglion neuron

Hearing loss is the most common sensory disorder that affects about 466 million people of all ages all over the world. Sensorineural hearing loss (SNHL) is the most common type of hearing loss. Various stress and injury could lead to the SNHL, including genetic factors, acoustic trauma, noise exposure, ototoxic drugs, inflammation or ageing. The irreversible loss of sensory hair cells and the following degeneration of spiral ganglion neurons are the main cause of SNHL. SNHL is not yet curable in the clinic because of the irreversible death of hair cells and the degeneration of spiral ganglion neurons in the cochlea.

Recent years, exciting animal studies on signalling pathway manipulation, gene therapy, and stem cell transplantation as well as pharmaceutical agents demonstrated that hair cells and spiral ganglion neurons could be regenerated and indicated that hearing loss might eventually be curable in the future. This Research Topic will focus on recent advances in the mechanism and prevention of hearing loss.

In this Research Topic, we invite authors to submit high-quality original research articles and reviews. Researchers and clinicians are encouraged to submit their work including basic research, clinical research and translational research. Potential topics include, but are not limited to:

• Gene therapy of hearing loss
• Hair cell and spiral ganglion neuron regeneration
• Spiral ganglion neuron refinement and retraction
• Application of bio-materials in improving the plasticity of spiral ganglion neuron

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Editors

Southeast University

VA Loma Linda Healthcare System, Veterans Health Administration, United States Department of Veterans Affairs

Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University

Eye and Ent Hospital, Fudan University

Department of Otolaryngology Head and Neck Surgery, PLA General Hospital

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203,005 Total views

158,894 Article views

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3,812 Topic views

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Frontiers in Cell and Developmental Biology

Molecular and Cellular Pathology

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