Stroke is one of the leading causes of death and disability worldwide. Currently, the only treatments available in the acute phase, that have demonstrated safety and effectiveness, are intravenous fibrinolytic treatment and mechanical thrombectomy. Unfortunately, even today many patients cannot benefit from these treatments due to contraindications, time of evolution of the symptoms, or restricted access to mechanical therapies that are currently only offered in highly sophisticated hospitals. The effectiveness of neuroprotective therapies has great potential, however, translation of most neuroprotective trials from the bench to the emergency room has failed so far.
Remote ischemic conditioning (RIC) represents a new paradigm in neuroprotective therapies, and it has the potential ability to protect the ischemic brain from injury until reperfusion and, later, to protect the brain from reperfusion injury. RIC consists of short and controlled cycles of ischemia-reperfusion applied to one limb during the establishment of cerebral ischemia (perconditioning), before (preconditioning), or after (postconditioning). Until now, the underlying mechanisms of remote ischemic conditioning are not clear and there is limited data about the clinical translation of RIPerC in ischemic stroke patients. Recent trials have only demonstrated the feasibility and security of this intervention in acute ischemic stroke patients.
We welcome research that would give evidence about underlying mechanisms, and biological and clinical effects of all types of RIC in cerebrovascular disease (ischemic and hemorrhagic stroke).
Areas of interest include, but are not limited to the following:
• Original Research papers and Reports of mechanisms of RIC: molecular, vascular, and systemic mechanisms; cell signaling
• Trial human Study Protocols of RIC in stroke
• Results of RIC in stroke patients
• Review Articles in the field of RIC
Stroke is one of the leading causes of death and disability worldwide. Currently, the only treatments available in the acute phase, that have demonstrated safety and effectiveness, are intravenous fibrinolytic treatment and mechanical thrombectomy. Unfortunately, even today many patients cannot benefit from these treatments due to contraindications, time of evolution of the symptoms, or restricted access to mechanical therapies that are currently only offered in highly sophisticated hospitals. The effectiveness of neuroprotective therapies has great potential, however, translation of most neuroprotective trials from the bench to the emergency room has failed so far.
Remote ischemic conditioning (RIC) represents a new paradigm in neuroprotective therapies, and it has the potential ability to protect the ischemic brain from injury until reperfusion and, later, to protect the brain from reperfusion injury. RIC consists of short and controlled cycles of ischemia-reperfusion applied to one limb during the establishment of cerebral ischemia (perconditioning), before (preconditioning), or after (postconditioning). Until now, the underlying mechanisms of remote ischemic conditioning are not clear and there is limited data about the clinical translation of RIPerC in ischemic stroke patients. Recent trials have only demonstrated the feasibility and security of this intervention in acute ischemic stroke patients.
We welcome research that would give evidence about underlying mechanisms, and biological and clinical effects of all types of RIC in cerebrovascular disease (ischemic and hemorrhagic stroke).
Areas of interest include, but are not limited to the following:
• Original Research papers and Reports of mechanisms of RIC: molecular, vascular, and systemic mechanisms; cell signaling
• Trial human Study Protocols of RIC in stroke
• Results of RIC in stroke patients
• Review Articles in the field of RIC
