Advances in Metabolic Mechanisms of Aging and Its Related Diseases, Volume II

Editorial

24 January 2023

Editorial: Advances in metabolic mechanisms of aging and its related diseases, Volume II

Daniele Lettieri-Barbato

Natascia Ventura

Raffaella Faraonio

and

Katia Aquilano

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0 citations

Editors

KATIA AQUILANO

University of Rome Tor Vergata

Daniele Lettieri Barbato

University of Rome Tor Vergata

Raffaella Faraonio

Department of Molecular Medicine and Medical Biotechnology, School of Medicine and Surgery, University of Naples Federico II

Natascia Ventura

Heinrich Heine University of Düsseldorf

Impact

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PHB deficiency and/or daf-2(e1370) mutation differentially affect lipid droplets. (A) Representative images of DGAT-2:GFP-labeled lipid droplets (LD) at the YA stage (Scale Bar: 20 μm). (B,C) Quantification of LD coverage (%) given by the ratio between the sum of the area of intestinal LDs versus the worm intestinal area times 100. All LDs (B) and LDs larger than 1 μm2 (C). Mean values from at least two independent biological replicates; error bars denote SD. ANOVA with post hoc Tukey test. P- values < 0.001 (***) < 0.0001 (****). (D) Representative images of ATGL-1:GFP at the YA stage. Scale Bar: 200 μm. (E–G) Quantifications of the mean intensity GFP signal per worm at days 0 (YA stage) (E), 6 (F), and 10 (G) of adulthood. Mean of at least two independent biological replicates; error bars denote SD. One-way ANOVA with post hoc Tukey multiple comparison test or, when appropriate, one-way Kruskal-Wallis test with post hoc Dunn’s Multiple comparison test, P-value < 0.05 (*) < 0.01 (**) < 0.001 (***) < 0.0001 (****). (H) Representative electron micrographs (EM) of worm cross-sections (top panels) and intestinal regions (middle and bottom panels) of wild type worms, PHB-depleted animals, daf-2 mutants and PHB-depleted daf-2 mutants at day 1 of adulthood. The intestine is delineated in orange. Bar sizes: 10 μm (top panels), 1 μm (middle panels) and 500 nm (bottom panels). (I,J) Quantification of intestinal LD coverage of all LDs (I) and LDs larger than 1μm2 (J) in each intestinal EM cross-section analyzed. At least three EM cross sections of the complete intestine were analyzed per genotype. One-way ANOVA with post hoc Tukey multiple comparison test, P-value < 0.01 (**) < 0.0001 (****).

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