Solid tumor tissues represent very heterogeneous networks regulated by interconnection between tumor microenvironment (TME) and cancer cells. TME contains extracellular matrix (ECM), growth factors, nutrients, blood and lymphatic vessels and non-cancer stromal cells. In particular, non-cancer stromal cells include endothelial cells, pericytes, immune cells, fibroblasts, myofibroblasts, cancer associated fibroblasts (CAFs), activated adipocytes, and mesenchymal stem cells (MSCs). However, each element of TME may be subjected to significant variations, depending on tumor type and localization, thus providing to each solid tumor distinctive features.
TME of solid tumors can be considered a niche generated and dramatically influenced by interactions with cancer cells. Moreover, these interactions support tumor development and dissemination, modulate immune surveillance and therapeutic resistance, and affect significantly clinical outcome. Therefore, a deepened comprehension of processes regulating the interactions between TME and cancer cells is crucial to develop therapeutic strategies targeting metastatic processes and overcome the formation of immunnosuppressive microenvironment and therapy resistances leading to cancer recurrence.
In this Research Topic, we welcome authors to submit Original Research and Review articles contributing to better understand the intricate networks of TME and cancer cell interactions that modulate tumor growth, immunosuppressive mechanism and therapy resistance.
Potential topics can include, but are not limited to:
- The role of TME and cancer cell interactions in TME remodelling
- TME and cancer cell interactions in tumor development
- Metastatic processes regulated by interplay between TME and cancer cells
- Interactions between TME and tumor cells leading to immune escape mechanisms and/or therapy resistance
- Therapeutic strategies targeting TME and cancer cell interactions
Solid tumor tissues represent very heterogeneous networks regulated by interconnection between tumor microenvironment (TME) and cancer cells. TME contains extracellular matrix (ECM), growth factors, nutrients, blood and lymphatic vessels and non-cancer stromal cells. In particular, non-cancer stromal cells include endothelial cells, pericytes, immune cells, fibroblasts, myofibroblasts, cancer associated fibroblasts (CAFs), activated adipocytes, and mesenchymal stem cells (MSCs). However, each element of TME may be subjected to significant variations, depending on tumor type and localization, thus providing to each solid tumor distinctive features.
TME of solid tumors can be considered a niche generated and dramatically influenced by interactions with cancer cells. Moreover, these interactions support tumor development and dissemination, modulate immune surveillance and therapeutic resistance, and affect significantly clinical outcome. Therefore, a deepened comprehension of processes regulating the interactions between TME and cancer cells is crucial to develop therapeutic strategies targeting metastatic processes and overcome the formation of immunnosuppressive microenvironment and therapy resistances leading to cancer recurrence.
In this Research Topic, we welcome authors to submit Original Research and Review articles contributing to better understand the intricate networks of TME and cancer cell interactions that modulate tumor growth, immunosuppressive mechanism and therapy resistance.
Potential topics can include, but are not limited to:
- The role of TME and cancer cell interactions in TME remodelling
- TME and cancer cell interactions in tumor development
- Metastatic processes regulated by interplay between TME and cancer cells
- Interactions between TME and tumor cells leading to immune escape mechanisms and/or therapy resistance
- Therapeutic strategies targeting TME and cancer cell interactions
