Extracellular Vesicles in Cardiovascular Diseases

89.9K

views

118

authors

17

articles

Extracellular Vesicles in Cardiovascular Diseases

89.9K

views

118

authors

17

articles

Editors

6

Junjie Yang

University of Maryland

Zhen-Ao Zhao

Hebei North University

Zhongjian Cheng

Center for Translational Medicine, Lewis Katz School of Medicine, Temple University

Phuong-Uyen Dinh

North Carolina State University

Ke Huang

North Carolina State University

Zhenhua Li

Southern Medical University

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About

Despite great advances in cardiovascular biology and medical therapy, CVDs remain the major cause of mortality and morbidity worldwide and have consistently been an important public health issue. Extracellular vesicles have attracted much attention in mediating intercellular communication during cardiovascular development and pathophysiology. Exosomal ncRNAs, including microRNAs, lncRNAs and circRNAs, are considered to be key players, offering a potential source of novel diagnostic and prognostic biomarkers for CVDs. Especially, stem cell-derived exosomes have a great potential as a novel alternative to cell therapies in cardiovascular disease owing to their biocompatibility and non-immunogenicity. However, hurdles regarding exosome purification, batch difference, dosage and untargeted delivery need to be overcome in preclinical and clinical practice.

This Research Topic aims to highlight the novel studies and strategies that might overcome current obstacles in cardiovascular translational medicine and their potential applications. Original research and review articles are welcome.

Specific themes we would like contributors to address include, but are not limited to:
1) Extracellular vesicles in differentiation of cardiovascular cells.
2) Extracellular vesicles in cardiovascular repair.
3) Extracellular vesicles in cardiovascular protection.
4) Extracellular vesicles in cardiovascular drug development and safety assay.
5) Extracellular vesicles in tissue engineering.
6) Extracellular vesicles in CVD diagnostic and prognostic.
7) Extracellular vesicles in CVD pathogenesis.
8) Extracellular vesicles in cardiovascular homeostasis.

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Editors

Junjie Yang

University of Maryland

Zhen-Ao Zhao

Hebei North University

Zhongjian Cheng

Center for Translational Medicine, Lewis Katz School of Medicine, Temple University

Phuong-Uyen Dinh

North Carolina State University

Ke Huang

North Carolina State University

Zhenhua Li

Southern Medical University

Impact

89,935 Total views

60,013 Article views

28,586 Article downloads

1,336 Topic views

Published In

Frontiers in Cardiovascular Medicine

Cardiovascular Biologics and Regenerative Medicine

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