The neonatal Fc receptor (FcRn): From Biology to Therapy

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Articles

ORIGINAL RESEARCH

Published on 20 Jul 2015

Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen

Zita Schneider
Péter Károly Jani
Bence Szikora
Attila Végh
Dorottya Kövesdi
Attila Iliás
Judit Cervenak
Péter Balogh
István Kurucz
Imre Kacskovics

doi 10.3389/fimmu.2015.00357

5,738 views
14 citations

GENERAL COMMENTARY

Published on 16 Jul 2015

Commentary: “There’s been a Flaw in Our Thinking”

E. Sally Ward
Raimund J. Ober

doi 10.3389/fimmu.2015.00351

4,253 views
6 citations

ORIGINAL RESEARCH

Published on 23 Apr 2015

Fully Human Monoclonal Antibody Inhibitors of the Neonatal Fc Receptor Reduce Circulating IgG in Non-Human Primates

Andrew E. Nixon
Jie Chen
Daniel J. Sexton
Arumugam Muruganandam
Alan J. Bitonti
Jennifer Dumont
Malini Viswanathan
Diana Martik
Dina Wassaf
3 more
Chris TenHoor

doi 10.3389/fimmu.2015.00176

10,484 views
48 citations

ORIGINAL RESEARCH

Published on 04 Feb 2015

Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions

Céline Monnet
Sylvie Jorieux
Rémi Urbain
Nathalie Fournier
Khalil Bouayadi
Christophe De Romeuf
Christian K. Behrens
Alexandre Fontayne
Philippe Mondon

doi 10.3389/fimmu.2015.00039

20,807 views
41 citations

REVIEW

Published on 26 Jan 2015

Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics

Kine Marita Knudsen Sand
Malin Bern
Jeannette Nilsen
Hanna Theodora Noordzij
Inger Sandlie
Jan Terje Andersen

doi 10.3389/fimmu.2014.00682

40,304 views
255 citations

ORIGINAL RESEARCH

Published on 05 Jan 2015

Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

Manoranjenni Chetty
Linzhong Li
Rachel Rose
Krishna Machavaram
Masoud Jamei
Amin Rostami-Hodjegan
Iain Gardner

doi 10.3389/fimmu.2014.00670

8,804 views
30 citations

MINI REVIEW

Published on 05 Jan 2015

Regulation of Immune Responses by the Neonatal Fc Receptor and Its Therapeutic Implications

Timo Rath
Kristi Baker
Michal Pyzik
Richard S. Blumberg

doi 10.3389/fimmu.2014.00664

9,876 views
58 citations

ORIGINAL RESEARCH

Published on 05 Nov 2014

Therapeutic Impact of Human Serum Albumin–Thioredoxin Fusion Protein on Influenza Virus-Induced Lung Injury Mice

Ryota Tanaka
Yu Ishima
Yuki Enoki
Kazuhiko Kimachi
Tatsuya Shirai
Hiroshi Watanabe
Victor T. G. Chuang
Toru Maruyama
Masaki Otagiri

doi 10.3389/fimmu.2014.00561

6,121 views
22 citations

OPINION

Published on 31 Oct 2014

There’s been a Flaw in Our Thinking

Clark L. Anderson

doi 10.3389/fimmu.2014.00540

3,735 views
9 citations

REVIEW

Published on 20 Oct 2014

IgG Subclasses and Allotypes: From Structure to Effector Functions

Gestur Vidarsson
Gillian Dekkers
Theo Rispens

doi 10.3389/fimmu.2014.00520

563,742 views
2,032 citations

REVIEW

Published on 27 Aug 2014

The Role of FcRn in Antigen Presentation

Kristi Baker
Timo Rath
Michal Pyzik
Richard S. Blumberg

doi 10.3389/fimmu.2014.00408

15,556 views
90 citations

REVIEW

Published on 30 May 2014

Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies

Caitlin Gillis
Aurélie Gouel-Chéron
Friederike Jönsson
Pierre Bruhns

doi 10.3389/fimmu.2014.00254

23,568 views
114 citations

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Articles

Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen

Commentary: “There’s been a Flaw in Our Thinking”

Fully Human Monoclonal Antibody Inhibitors of the Neonatal Fc Receptor Reduce Circulating IgG in Non-Human Primates

Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions

Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics

Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

Regulation of Immune Responses by the Neonatal Fc Receptor and Its Therapeutic Implications

Therapeutic Impact of Human Serum Albumin–Thioredoxin Fusion Protein on Influenza Virus-Induced Lung Injury Mice

There’s been a Flaw in Our Thinking

IgG Subclasses and Allotypes: From Structure to Effector Functions

The Role of FcRn in Antigen Presentation

Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies

Frontiers in Immunology

Participating Journals

Impact