About this Research Topic
Nuclear Magnetic Resonance is a well-established technique that, at the same time, is rapidly evolving to study a wide array of topics related to biomolecular structure, dynamics, and function. Proteins, DNA, lipids, and other biomolecules and their complexes can be studied in solution and solids thus covering a wide range of sample conditions. Advances in magic-angle spinning solid-state NMR allow to study in detail protein aggregates and amyloids, molecular assemblies, intact viruses, membrane proteins and more. Such NMR studies are often combined with advanced calculation tools and integrated with other structural biology techniques such as X-ray crystallography and cryo electron microscopy. Continuous progress in hardware development, sample preparation techniques and integrated approaches facilitate the study of systems with ever growing sophistication at unprecedented resolution.
This Research Topic aims to demonstrate the strength of magic-angle spinning (MAS) solid-state NMR as a stand-alone, or as an integrated technique, in analyzing and characterizing proteins, protein assemblies, and other biomolecular systems. Although this vision has existed for at least the last two decades, recent advances have transformed the method into a true tool for biology, as detailed below.
The contributions will cover state-of-the-art methods and representative applications in the form of original research articles and reviews covering, but not limited to, the following:
Applications:
• Protein aggregates and amyloids
• Membrane proteins
• Protein assemblies and protein complexes
• Integrative approaches for structure determination
• Surface-bound proteins
• Viruses and viral proteins
• RNA, DNA and their complexes
• Interplay of proteins and inorganic material
Methods:
• Proton detection
• Accelerated methods
• Molecular dynamics and DFT combined with MAS NMR
• Structure determination
• Protein dynamics
• New/Optimized Pulse sequences
This Research Topic aims to demonstrate the strength of magic-angle spinning (MAS) solid-state NMR as a stand-alone, or as an integrated technique, in analyzing and characterizing proteins, protein assemblies, and other biomolecular systems. Although this vision has existed for at least the last two decades, recent advances have transformed the method into a true tool for biology, as detailed below.
The contributions will cover state-of-the-art methods and representative applications in the form of original research articles and reviews covering, but not limited to, the following:
Applications:
• Protein aggregates and amyloids
• Membrane proteins
• Protein assemblies and protein complexes
• Integrative approaches for structure determination
• Surface-bound proteins
• Viruses and viral proteins
• RNA, DNA and their complexes
• Interplay of proteins and inorganic material
Methods:
• Proton detection
• Accelerated methods
• Molecular dynamics and DFT combined with MAS NMR
• Structure determination
• Protein dynamics
• New/Optimized Pulse sequences
Keywords: Magic-angle spinning, solid-state NMR, integrative structure biology, protein structure and dynamics, protein complexes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
