Gut Microbial Response to Host Metabolic Phenotypes: Volume 1

It is increasingly apparent that gut microbiota performs functions crucial to the host, such as regulating host physiology and influencing host health through bacterial metabolites, microRNA, bacteriocin, and microbiota sensing pathways. Meanwhile, gut microbiota dysbiosis is associated with various diseases, in particular, with metabolic dysfunctions. Manipulation of gut ecology to restore optimal microbiota diversity, for example through intake of probiotics, prebiotics, and other gut microbiota modulating nutrients, has been now widely explored and is of increasing interest in a clinical setting. Gut microbial response to host metabolic alterations is currently an area of intense investigation and hopefully will lead a more detailed understanding of this cross talk and its effects on distal organs or tissues.

Authors are encouraged to submit the microbial structure and functional assessments in different metabolic phenotypes accompanied by targeted or non-targeted (meta)metabolomics, (meta)transcriptomics, and (meta)proteomics approaches in an integrative manner. A detailed molecular study of how dietary specific nutrients influence the ecology of the gut microenvironment to produce metabolic benefits will be also considered. In this Research Topic, we welcome submissions of Original Research articles as well as Reviews.